Beneficios del ejercicio supervisado en la rehabilitación de pacientes oncológicos: una revisión sistemática

Autores/as

DOI:

https://doi.org/10.47197/retos.v68.110146

Palabras clave:

Cáncer, rehabilitación postoperatoria, ejercicio físico, calidad de vida, funcionalidad física

Resumen

Introducción: El cáncer y sus tratamientos deterioran la calidad de vida, pero hoy sabemos que el ejercicio físico, especialmente cuando es supervisado, puede marcar una gran diferencia. Mejora la salud general, alivia síntomas como la fatiga y la ansiedad, y ayuda a recuperar capacidades físicas y respuestas metabólicas importantes.

Objetivos: Examinar la evidencia científica sobre los beneficios del ejercicio supervisado en la rehabilitación de pacientes oncológicos, con el fin de identificar las mejores prácticas y estrategias de intervención que optimicen los resultados en su salud general.

Métodos: Se realizó una búsqueda en PubMed, Web of Science, Cochrane Library, Scopus y Google Scholar, utilizando términos específicos y criterios de inclusión para estudios publicados entre 2013 y 2024. Se identificaron 1,169 registros (PubMed =677, Scopus =79, Web of Science =287, Cochrane Library =126). Tras eliminar duplicados (n=587) y registros no aptos (n=181), se examinaron 348 registros, excluyendo 768. Finalmente, se incluyeron 19 ensayos clínicos aleatorios, con 2,117 participantes y una edad promedio de 44.41 años.

Conclusión: El ejercicio físico mejora la salud física y mental de pacientes con cáncer, aumentando la fuerza muscular y la calidad de vida, y reduciendo la fatiga y la depresión. También favorece la salud ósea y metabólica, reforzando la importancia de su integración en los programas de tratamiento y recuperación del cáncer.

Biografía del autor/a

Eduardo Cruzat Bravo, Universidad santo tomas

Kinesiólogo-Magister en educación, aspectos psicológicos de la educación USS y Magister en gestión en educación UST Dr. en ciencias del desarrollo humano

Felipe Suárez Rojas, Universidad santo tomas

Estudiante de Kinesiologia

Citas

Adams, A., Akezaki, Y., Nakata, E., Kikuuchi, M., Tominaga, R., Kurokawa, H., Okamoto, M., Hamada, M., Aogi, K., Ohsumi, S., & Sugihara, S. (2021). Factors affecting participation in leisure activities in patients after breast cancer surgery. Healthcare (Basel), 9(8), 1078. https://doi.org/10.3390/healthcare9081078

Ab, A., Rhibi, O., Ouerghi, H., Saeidi, A., & Zouhal, H. (2018). Effects of recovery mode during high intensity interval training on glucoregulatory hormones and glucose metabolism in response to maximal exercise. Journal of Athletic Enhancement, 7(3). https://doi.org/10.4172/2324-9080.1000292

Adamsen, L., Quist, M., Andersen, C., Møller, T., Herrstedt, J., Kronborg, D., Baadsgaard, M. T., Vistisen, K., Midtgaard, J., Christiansen, B., Stage, M., Kronborg, M. T., & Rørth, M. (2009). Effect of a multi-modal high intensity exercise intervention in cancer patients undergoing chemotherapy: Ran-domised controlled trial. BMJ (Clinical Research Ed.), 339, b3410. https://doi.org/10.1136/bmj.b3410

American Heart Association Council on Clinical Cardiology and Council on Nutrition, Physical Activity, and Metabolism. (2007). Physical activity and public health update. Circulation, 116(5), 572–584. https://doi.org/10.1161/circulationaha.107.185214

Ammitzbøll, G., Johansen, C., Lanng, C., Andersen, E. W., Kroman, N., Zerahn, B., Hyldegaard, O., Wit-tenkamp, M. C., & Dalton, S. O. (2019). Progressive resistance training to prevent arm lymphedema in the first year after breast cancer surgery: Results of a randomized controlled trial. Cancer, 125(10), 1683–1692. https://doi.org/10.1002/cncr.31962

Anderson, G. L., Chlebowski, R. T., Aragaki, A. K., Kuller, L. H., Manson, J. E., Gass, M., Bluhm, E., Connelly, S., Hubbell, F. A., Lane, D., Martin, L., Ockene, J., Rohan, T., Schenken, R., & Wactawski-Wende, J. (2012). Conjugated equine oestrogen and breast cancer incidence and mortality in postmeno-pausal women with hysterectomy: Extended follow-up of the Women’s Health Initiative ran-domised placebo-controlled trial. The Lancet Oncology, 13(5), 476–486. https://doi.org/10.1016/S1470-2045(12)70075-X

Anderson, L., Oldridge, N., Thompson, D. R., Zwisler, A.-D., Rees, K., Martin, N., & Taylor, R. S. (2016). Exercise-based cardiac rehabilitation for coronary heart disease. Journal of the American Col-lege of Cardiology, 67(1), 1–12. https://doi.org/10.1016/j.jacc.2015.10.044

Andreopoulou, E., & Hortobagyi, G. N. (2008). Prognostic factors in metastatic breast cancer: Successes and challenges toward individualized therapy. Journal of Clinical Oncology, 26(22), 3660–3662. https://doi.org/10.1200/jco.2008.16.1026

Angadi, S. S., Mookadam, F., Lee, C. D., Tucker, W. J., Haykowsky, M. J., & Gaesser, G. A. (2015). High-intensity interval training vs. moderate-intensity continuous exercise training in heart failure with preserved ejection fraction: A pilot study. Journal of Applied Physiology, 119(6), 753–758. https://doi.org/10.1152/japplphysiol.00518.2014

Antunes, P., Joaquim, A., Sampaio, F., Nunes, C., Ascensão, A., Vilela, E., Teixeira, M., Capela, A., Amarelo, A., Marques, C., Viamonte, S., Alves, A., & Esteves, D. (2023). Effects of exercise training on cardiac toxicity markers in women with breast cancer undergoing chemotherapy with anthracyclines: A randomized controlled trial. European Journal of Preventive Cardiology, 30(9), 844–855. https://doi.org/10.1093/eurjpc/zwad063

Artero, E. G., Lee, D.-C., Ruiz, J. R., Sui, X., Ortega, F. B., Church, T. S., Lavie, C. J., Castillo, M. J., & Blair, S. N. (2011). A prospective study of muscular strength and all-cause mortality in men with hypertension. Journal of the American College of Cardiology, 57(18), 1831–1837. https://doi.org/10.1016/j.jacc.2010.12.025

Bangsbo, J., Blackwell, J., Boraxbekk, C.-J., Caserotti, P., Dela, F., Evans, A. B., Jespersen, A. P., Gliemann, L., Kramer, A. F., Lundbye-Jensen, J., Mortensen, E. L., Lassen, A. J., Gow, A. J., Harridge, S. D. R., Hellsten, Y., Kjaer, M., Kujala, U. M., Rhodes, R. E., Pike, E. C. J., … Viña, J. (2019). Copenhagen Consensus Statement 2019: Physical activity and ageing. British Journal of Sports Medicine, 53(14), 856–858. https://doi.org/10.1136/bjsports-2018-100451

Bedillion, M. F., Ansell, E. B., & Thomas, G. A. (2019). Cancer treatment effects on cognition and depres-sion: The moderating role of physical activity. Breast (Edinburgh, Scotland), 44, 73–80. https://doi.org/10.1016/j.breast.2019.01.004

Benfica, P. do A., Aguiar, L. T., Brito, S. A. F. de, Bernardino, L. H. N., Teixeira-Salmela, L. F., & Faria, C. D. C. de M. (2018). Reference values for muscle strength: A systematic review with a descriptive meta-analysis. Brazilian Journal of Physical Therapy, 22(5), 355–369. https://doi.org/10.1016/j.bjpt.2018.02.006

Bhatt, N. R., Boland, M. R., McGovern, R., Lal, A., Tormey, S., Lowery, A. J., & Merrigan, B. A. (2018). Up-per limb lymphedema in breast cancer patients in the era of Z0011, sentinel lymph node biopsy and breast conservation. Irish Journal of Medical Science, 187(2), 327–331. https://doi.org/10.1007/s11845-017-1658-0

Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 coun-tries. CA: A Cancer Journal for Clinicians, 68(6), 394–424. https://doi.org/10.3322/caac.21492

Britt, K. L., Cuzick, J., & Phillips, K.-A. (2020). Key steps for effective breast cancer prevention. Nature Reviews Cancer, 20(8), 417–436. https://doi.org/10.1038/s41568-020-0266-x

Campos, Y., Vianna, J., Guimarães, M., Domínguez, R., Azevedo, P. H., Ana, L. S., Leitão, L., Novaes, J., Silva, S., & Reis, V. (2020). Comparison of methods to determine the lactate threshold during leg press exercise in long-distance runners. Motriz: Revista de Educação Física. UNESP, 26(2). https://doi.org/10.1590/s1980-6574202000020207

Caruso, F. R., Junior, J. C. B., Mendes, R. G., Sperling, M. P., Arakelian, V. M., Bassi, D., Arena, R., & Borghi-Silva, A. (2016). Hemodynamic and metabolic response during dynamic and resistance exercise in different intensities: A cross-sectional study on implications of intensity on safety and symptoms in patients with coronary disease. American Journal of Cardiovascular Disease, 6(2), 36–45.

Carvalho, L., Junior, R. M., Barreira, J., Schoenfeld, B. J., Orazem, J., & Barroso, R. (2022). Muscle hypertrophy and strength gains after resistance training with different volume-matched loads: A systematic review and meta-analysis. Applied Physiology, Nutrition, and Metabolism, 47(4), 357–368. https://doi.org/10.1139/apnm-2021-0515

Cheng, K. K. F., Lim, Y. T. E., Koh, Z. M., & Tam, W. W. S. (2017). Home-based multidimensional survivorship programmes for breast cancer survivors. Cochrane Database of Systematic Reviews, 2017(8). https://doi.org/10.1002/14651858.cd011152.pub2

Dang, L., & Su, S.-S. M. (2017). Isocitrate dehydrogenase mutation and (R)-2-hydroxyglutarate: From basic discovery to therapeutics development. Annual Review of Biochemistry, 86, 305–331.

de Haas, E. C., Oosting, S. F., Lefrandt, J. D., Wolffenbuttel, B. H. R., Sleijfer, D. T., & Gietema, J. A. (2010). The metabolic syndrome in cancer survivors. The Lancet Oncology, 11(2), 193–203. https://doi.org/10.1016/S1470-2045(09)70287-6

de Jesus Leite, M. A. F., Mariano, I. M., Dechichi, J. G. C., Giolo, J. S., Gonçalves, Á. de C., & Puga, G. M. (2021). Exercise training and detraining effects on body composition, muscle strength and lipid, inflammatory and oxidative markers in breast cancer survivors under tamoxifen treatment. Li-fe Sciences, 284, 119924. https://doi.org/10.1016/j.lfs.2021.119924

de la Rosa Oliva, F., Meneses García, A., Ruiz Calzada, H., Astudillo de la Vega, H., Bargalló Rocha, E., Lara-Medina, F., Alvarado Miranda, A., Matus-Santos, J., Flores-Díaz, D., Oñate-Acuña, L. F., Gutiérrez-Salmeán, G., Ruiz García, E., & Ibarra, A. (2019). Effects of omega-3 fatty acids supplementation on neoadjuvant chemotherapy-induced toxicity in patients with locally advanced breast can-cer: A randomized, controlled, double-blinded clinical trial. Nutrición Hospitalaria. https://doi.org/10.20960/nh.2338

Dieli-Conwright, C. M., Courneya, K. S., Demark-Wahnefried, W., Sami, N., Lee, K., Sweeney, F. C., Stew-art, C., Buchanan, T. A., Spicer, D., Tripathy, D., Bernstein, L., & Mortimer, J. E. (2018). Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: A randomized controlled trial. Breast Cancer Research, 20(1). https://doi.org/10.1186/s13058-018-1051-6

Dong, X., Yi, X., Gao, D., Gao, Z., Huang, S., Chao, M., Chen, W., & Ding, M. (2019). The effects of the com-bined exercise intervention based on internet and social media software (CEIBISMS) on quality of life, muscle strength and cardiorespiratory capacity in Chinese postoperative breast cancer patients: A randomized controlled trial. Health and Quality of Life Outcomes, 17(1). https://doi.org/10.1186/s12955-019-1183-0

Esteban-Simón, A., Díez-Fernández, D. M., Rodríguez-Pérez, M. A., Artés-Rodríguez, E., Casimiro-Andújar, A. J., & Soriano-Maldonado, A. (2024). Does a resistance training program affect between-arms volume difference and shoulder-arm disabilities in female breast cancer survivors? The role of surgery type and treatments. Secondary outcomes of the EFICAN trial. Archives of Physical Medicine and Rehabilitation, 105(4), 647–654. https://doi.org/10.1016/j.apmr.2023.11.010

Eyre, H., Kahn, R., Robertson, R. M., Clark, N. G., Doyle, C., Hong, Y., Gansler, T., Glynn, T., Smith, R. A., Taubert, K., Thun, M. J., & ACS/ADA/AHA Collaborative Writing Committee. (2004). Preventing cancer, cardiovascular disease, and diabetes: A common agenda for the American Cancer Society, the American Diabetes Association, and the American Heart Association. Circulation, 109(25), 3244–3255. https://doi.org/10.1161/01.CIR.0000133321.00456.00

Falstie-Jensen, A. M., Esen, B. Ö., Kjærsgaard, A., Lorenzen, E. L., Jensen, J. D., Reinertsen, K. V., Dekkers, O. M., Ewertz, M., & Cronin-Fenton, D. P. (2020). Incidence of hypothyroidism after treatment for breast cancer—A Danish matched cohort study. Breast Cancer Research, 22(1). https://doi.org/10.1186/s13058-020-01337-z

Falz, R., Bischoff, C., Thieme, R., Tegtbur, U., Hillemanns, P., Stolzenburg, J.-U., Aktas, B., Bork, U., Weitz, J., Lässing, J., Leps, C., Voß, J., Lordick, F., Schulze, A., Gockel, I., & Busse, M. (2023). Effect of home-based online training and activity feedback on oxygen uptake in patients after surgical cancer therapy: A randomized controlled trial. BMC Medicine, 21(1). https://doi.org/10.1186/s12916-023-03010-6

Fang, S.-Y., Wang, Y.-L., Lu, W.-H., Lee, K.-T., Kuo, Y.-L., & Fetzer, S. J. (2020). Long-term effectiveness of an E-based survivorship care plan for breast cancer survivors: A quasi-experimental study. Pa-tient Education and Counseling, 103(3), 549–555. https://doi.org/10.1016/j.pec.2019.09.012

Farrell, S. W., Braun, L., Barlow, C. E., Cheng, Y. J., & Blair, S. N. (2002). The relation of body mass index, cardiorespiratory fitness, and all‐cause mortality in women. Obesity Research, 10(6), 417–423. https://doi.org/10.1038/oby.2002.58

Fernandez-Muñoz, J. M., Guerrero-Gimenez, M. E., Ciocca, L. A., Germanó, M. J., & Zoppino, F. C. M. (2024). Mutational landscape of HSP family on human breast cancer. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-61807-8

Folorunso, S. A., Abdus-Salam, A. A., Ntekim, A. I., Oladeji, A. A., Jimoh, M. A., & Folorunso, A. O. (2024). Sociodemographic and treatment-related correlates of fatigue in breast cancer survivors at an oncology clinic in Nigeria. ecancermedicalscience, 18, Article 1659. https://doi.org/10.3332/ecancer.2024.1659

Fukushima, T., Suzuki, K., Tanaka, T., Okayama, T., Inoue, J., Morishita, S., & Nakano, J. (2024). Global quality of life and mortality risk in patients with cancer: A systematic review and meta-analysis. Quality of Life Research. https://doi.org/10.1007/s11136-024-03691-3

Furmaniak, A. C., Menig, M., & Markes, M. H. (2016). Exercise for women receiving adjuvant therapy for breast cancer. Cochrane Database of Systematic Reviews, 2016(9). https://doi.org/10.1002/14651858.cd005001.pub3

Geidl, W., Abu-Omar, K., Weege, M., Messing, S., & Pfeifer, K. (2020). German recommendations for physical activity and physical activity promotion in adults with noncommunicable diseases. In-ternational Journal of Behavioral Nutrition and Physical Activity, 17(1). https://doi.org/10.1186/s12966-020-0919-x

Gülören, G., Doğan, Y., Özgül, S., Gürşen, C., Çınar, G. N., İpekten, F., & Akbayrak, T. (2023). Acute effects of remedial exercises with and without compression on breast-cancer-related lymphedema. Healthcare (Basel), 11(22), 2949. https://doi.org/10.3390/healthcare11222949

Hariharan, R., Hood, L., & Price, N. D. (2024). A data-driven approach to improve wellness and reduce recurrence in cancer survivors. Frontiers in Oncology, 14, 1397008. https://doi.org/10.3389/fonc.2024.1397008

Hasenoehrl, T., Keilani, M., Palma, S., & Crevenna, R. (2020). Resistance exercise and breast cancer-related lymphedema – A systematic review update. Disability and Rehabilitation, 42(1), 26–35. https://doi.org/10.1080/09638288.2018.1514663

Hiensch, A. E., Mijwel, S., Bargiela, D., Wengström, Y., May, A. M., & Rundqvist, H. (2021). Inflammation mediates exercise effects on fatigue in patients with breast cancer. Medicine and Science in Sports and Exercise, 53(3), 496–504. https://doi.org/10.1249/MSS.0000000000002490

Holmen Olofsson, G., Mikkelsen, M. K., Ragle, A. M., Christiansen, A. B., Olsen, A. P., Heide-Ottosen, L., Horsted, C. B., Pedersen, C. M. S., Engell-Noerregaard, L., Lorentzen, T., Persson, G. F., Vinther, A., Nielsen, D. L., & Thor Straten, P. (2022). High intensity aerobic exercise training and immune cell mobilization in patients with lung cancer (HI AIM) – A randomized controlled trial. BMC Cancer, 22(1), 246. https://doi.org/10.1186/s12885-022-09349-y

Jakobsen, M., Kolodziejczyk, C., Jensen, M. S., Poulsen, P. B., Khan, H., Kümler, T., & Andersson, M. (2021). Cardiovascular disease in women with breast cancer – A nationwide cohort study. BMC Cancer, 21(1). https://doi.org/10.1186/s12885-021-08716-5

Kim, J., Kim, Y., Oh, J. W., & Lee, S. (2024). Sex differences of the association between handgrip strength and health-related quality of life among patients with cancer. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-60710-6

King, A. C., Powell, K. E., & Kraus, W. E. (2019). The US physical activity guidelines advisory committee report—Introduction. Medicine and Science in Sports and Exercise, 51(6), 1203–1205. https://doi.org/10.1249/MSS.0000000000001946

Kaufman, C. K., Mosimann, C., Fan, Z. P., Yang, S., Thomas, A. J., Ablain, J., … Zon, L. I. (2016). A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Sci-ence, 351(6272), aad2197. https://doi.org/10.1126/science.aad2197

Kavak, S. K., & Kavak, E. E. (2024). Fatigue and sleep quality improvement through complete decongestive therapy in postmastectomy lymphedema: An investigative analysis. Supportive Care in Cancer, 32(6). https://doi.org/10.1007/s00520-024-08590-4

Lacio, M., Vieira, J. G., Trybulski, R., Campos, Y., Santana, D., Filho, J. E., Novaes, J., Vianna, J., & Wilk, M. (2021). Effects of resistance training performed with different loads in untrained and trained male adult individuals on maximal strength and muscle hypertrophy: A systematic review. International Journal of Environmental Research and Public Health, 18(21), 11237. https://doi.org/10.3390/ijerph182111237

LaFave, L. M., Kartha, V. K., Ma, S., Meli, K., Del Priore, I., Lareau, C., … Buenrostro, J. D. (2020). Epigenomic state transitions characterize tumor progression in mouse lung adenocarcinoma. Cancer Cell, 38(2), 212–228.e13. https://doi.org/10.1016/j.ccell.2020.05.012

Lahart, I. M., Metsios, G. S., Nevill, A. M., & Carmichael, A. R. (2018). Physical activity for women with breast cancer after adjuvant therapy. Cochrane Database of Systematic Reviews, 2018(1), CD011292. https://doi.org/10.1002/14651858.CD011292.pub2

Lee, K., Tripathy, D., Demark-Wahnefried, W., Courneya, K. S., Sami, N., Bernstein, L., Spicer, D., Buchan-an, T. A., Mortimer, J. E., & Dieli-Conwright, C. M. (2019). Effect of aerobic and resistance exercise intervention on cardiovascular disease risk in women with early-stage breast cancer: A randomized clinical trial. JAMA Oncology, 5(5), 710. https://doi.org/10.1001/jamaoncol.2019.0038

Li, Q., Pan, X., Li, X., & Huang, W. (2022). Association of physical activity intensity with all-cause mortal-ity in cancer survivors: A national prospective cohort study. Cancers, 14(23), 5760. https://doi.org/10.3390/cancers14235760

Li, Z., Zhi, P., Yuan, Z., García-Ramos, A., & King, M. (2024). Feasibility of vertical force–velocity profiles to monitor changes in muscle function following different fatigue protocols. European Journal of Applied Physiology, 124(1), 365–374. https://doi.org/10.1007/s00421-023-05283-4

Liguori, G. (Ed.). (2021). Directrices del ACSM para pruebas de ejercicio y prescripción. Wolters Kluwer Salud.

Lopez, P., Radaelli, R., Taaffe, D. R., Galvão, D. A., Newton, R. U., Nonemacher, E. R., Wendt, V. M., Bassa-nesi, R. N., Turella, D. J. P., & Rech, A. (2022). Moderators of resistance training effects in over-weight and obese adults: A systematic review and meta-analysis. Medicine and Science in Sports and Exercise, 54(11), 1804–1816. https://doi.org/10.1249/MSS.0000000000002984

Lopez, P., Radaelli, R., Taaffe, D. R., Newton, R. U., Galvão, D. A., Trajano, G. S., Teodoro, J. L., Kraemer, W. J., Häkkinen, K., & Pinto, R. S. (2021). Resistance training load effects on muscle hypertrophy and strength gain: Systematic review and network meta-analysis. Medicine and Science in Sports and Exercise, 53(6), 1206–1216. https://doi.org/10.1249/MSS.0000000000002585

Lovelace, D. L., McDaniel, L. R., & Golden, D. (2019). Long-term effects of breast cancer surgery, treatment, and survivor care. Journal of Midwifery & Women’s Health, 64(6), 713–724. https://doi.org/10.1111/jmwh.13012

Lowe, S. S., Tan, M., Faily, J., Watanabe, S. M., & Courneya, K. S. (2016). Physical activity in advanced cancer patients: A systematic review protocol. Systematic Reviews, 5(1), 1–6. https://doi.org/10.1186/s13643-016-0220-x

Luz, R. P. C., Simao Haddad, C. A., Rizzi, S. K. L. de A., Elias, S., Nazario, A. C. P., & Facina, G. (2018). Complex therapy physical alone or associated with strengthening exercises in patients with lymphedema after breast cancer treatment: A controlled clinical trial. Asian Pacific Journal of Cancer Prevention, 19(5), 1405–1410. https://doi.org/10.22034/APJCP.2018.19.5.1405

Macari, A., Soberanis-Pina, P., Varela-Santoyo, E., Valle-Sanchez, M. A., Leal-Hidalgo, J. L., Torres-Guillen, V. M., Motola-Kuba, D., Ruiz-Morales, J. M., & Dorantes-Heredia, R. (2021). Prevalence and molecular profile of breast carcinoma using immunohistochemistry markers in Mexican women. World Journal of Oncology, 12(4), 119–123. https://doi.org/10.14740/wjon1392

Martínez Aguirre-Betolaza, A., Dobaran Amezua, A., Yagin, F. H., Cacicedo, J., Olasagasti-Ibargoien, J., & Castañeda-Babarro, A. (2024). Do oncologists recommend the “pill” of physical activity in their practice? Answers from the oncologist and patients’ perspectives. Cancers, 16(9), 1720. https://doi.org/10.3390/cancers16091720

Maximov, P. Y., Abderrahman, B., Fanning, S. W., Sengupta, S., Fan, P., Curpan, R. F., Rincon, D. M. Q., Greenland, J. A., Rajan, S. S., Greene, G. L., & Jordan, V. C. (2018). Endoxifen, 4-hydroxytamoxifen, and an estrogenic derivative modulate apoptosis mediated by the estrogen receptor complex in breast cancer. Molecular Pharmacology, 94(2), 812–822. https://doi.org/10.1124/mol.117.111385

Medysky, M. E., Temesi, J., Culos-Reed, S. N., & Millet, G. Y. (2017). Exercise, sleep and cancer-related fatigue: Are they related? Neurophysiologie Clinique, 47(2), 111–122. https://doi.org/10.1016/j.neucli.2017.03.001

Merino Bonilla, J. A., Torres Tabanera, M., & Ros Mendoza, L. H. (2017). El cáncer de mama en el siglo XXI: De la detección precoz a los nuevos tratamientos. Radiología, 59(5), 368–379. https://doi.org/10.1016/j.rx.2017.06.003

Millard, A. L., Valli, P. V., Stussi, G., Mueller, N. J., Yung, G. P., & Seebach, J. D. (2013). Brief exercise in-creases peripheral blood NK cell counts without immediate functional changes, but impairs their responses to ex vivo stimulation. Frontiers in Immunology, 4, 125. https://doi.org/10.3389/fimmu.2013.00125

Mishra, S. I., Scherer, R. W., Snyder, C., Geigle, P. M., Berlanstein, D. R., & Topaloglu, O. (2012). Exercise interventions on health-related quality of life for people with cancer during active treatment. Cochrane Database of Systematic Reviews, 2012(8), CD008465. https://doi.org/10.1002/14651858.CD008465.pub2

Mikkelsen, M. K., Lund, C. M., Vinther, A., Tolver, A., Ragle, A. M., Johansen, J. S., Chen, I., Engell-Noerregaard, L., Larsen, F. O., Zerahn, B., Nielsen, D. L., & Jarden, M. (2018). Engaging the older cancer patient; Patient Activation through Counseling, Exercise and Mobilization—Pancreatic, Biliary Tract and Lung cancer (PACE-Mobil-PBL) study protocol of a randomized controlled trial. BMC Cancer, 18(1), 934. https://doi.org/10.1186/s12885-018-4835-2

Morris, J. P., Yashinskie, J. J., Koche, R., Chandwani, R., Tian, S., Chen, C.-C., … Lowe, S. W. (2019). α-Ketoglutarate links p53 to cell fate during tumour suppression. Nature, 573, 595–599. https://doi.org/10.1038/s41586-019-1537-6

Moungthard, H., Thinkhamrop, K., Chamadol, N., Laopaiboon, V., Thinkhamrop, B., & Kelly, M. (2023). Association of cholangiocarcinoma among people with periductal fibrosis. Asian Pacific Journal of Cancer Prevention, 24(12), 4147–4154. https://doi.org/10.31557/APJCP.2023.24.12.4147

Muñoz-Martínez, F. A., Rubio-Arias, J. Á., Ramos-Campo, D. J., & Alcaraz, P. E. (2017). Effectiveness of resistance circuit-based training for maximum oxygen uptake and upper-body one-repetition maximum improvements: A systematic review and meta-analysis. Sports Medicine, 47(12), 2553–2568. https://doi.org/10.1007/s40279-017-0773-4

Naczk, A., Huzarski, T., Doś, J., Górska-Doś, M., Gramza, P., Gajewska, E., & Naczk, M. (2022). Impact of inertial training on muscle strength and quality of life in breast cancer survivors. International Journal of Environmental Research and Public Health, 19(6), 3278. https://doi.org/10.3390/ijerph19063278

Natalucci, V., Ferri Marini, C., De Santi, M., Annibalini, G., Lucertini, F., Vallorani, L., Panico, A. R., Sisti, D., Saltarelli, R., Donati Zeppa, S., Agostini, D., Gervasi, M., Baldelli, G., Grassi, E., Nart, A., Rossato, M., Biancalana, V., Piccoli, G., Benelli, P., … Barbieri, E. (2023). Movement and health beyond care, MoviS: Study protocol for a randomized clinical trial on nutrition and exercise educational programs for breast cancer survivors. Trials, 24(1). https://doi.org/10.1186/s13063-023-07153-y

O’Connor, C. M., Whellan, D. J., Lee, K. L., Keteyian, S. J., Cooper, L. S., Ellis, S. J., … Piña, I. L. (2009). Effi-cacy and safety of exercise training in patients with chronic heart failure: HF-ACTION random-ized controlled trial. JAMA, 301(14), 1439–1450. https://doi.org/10.1001/jama.2009.454

Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., … Alonso-Fernández, S. (2021). Declaración PRISMA 2020: Una guía actualizada para la publicación de revisiones sistemáticas. Revista Española de Cardiología, 74(9), 790–799. https://doi.org/10.1016/j.recesp.2021.06.016

Piercy, K. L., Troiano, R. P., Ballard, R. M., Carlson, S. A., Fulton, J. E., Galuska, D. A., George, S. M., & Olson, R. D. (2018). The physical activity guidelines for Americans. JAMA, 320(19), 2020–2028. https://doi.org/10.1001/jama.2018.14854

Pinto, B. M., Patel, A., Ostendorf, D. M., Huebschmann, A. G., Dunsiger, S. I., & Kindred, M. M. (2024). Adapting an efficacious peer-delivered physical activity program for survivors of breast cancer for web platform delivery: Protocol for a 2-phase study. JMIR Research Protocols, 13, e52494. https://doi.org/10.2196/52494

Prue, G., Rankin, J., Allen, J., Gracey, J., & Cramp, F. (2006). Cancer-related fatigue: A critical appraisal. European Journal of Cancer, 42(7), 846–863. https://doi.org/10.1016/j.ejca.2005.11.026

Pudkasam, S., Polman, R., Pitcher, M., Fisher, M., Chinlumprasert, N., Stojanovska, L., & Apostolopoulos, V. (2018). Physical activity and breast cancer survivors: Importance of adherence, motivation-al interviewing and psychological health. Maturitas, 116, 66–72. https://doi.org/10.1016/j.maturitas.2018.07.010

Quindry, J. C., Franklin, B. A., Chapman, M., Humphrey, R., & Mathis, S. (2019). Benefits and risks of high-intensity interval training in patients with coronary artery disease. The American Journal of Cardiology, 123(8), 1370–1377. https://doi.org/10.1016/j.amjcard.2019.01.008

Quist, M., Adamsen, L., Rørth, M., Laursen, J. H., Christensen, K. B., & Langer, S. W. (2015). El impacto de una intervención de ejercicio multidimensional en la capacidad física y funcional, la ansiedad y la depresión en pacientes con cáncer de pulmón en etapa avanzada sometidos a quimioterapia. Terapias Integradoras contra el Cáncer, 14(4), 341–349. https://doi.org/10.1177/1534735415572887

Quist, M., Langer, S. W., Rørth, M., Christensen, K. B., & Adamsen, L. (2013). “EXHALE”: Exercise as a strategy for rehabilitation in advanced stage lung cancer patients: A randomized clinical trial comparing the effects of 12 weeks supervised exercise intervention versus usual care. BMC Cancer, 13, 477. https://doi.org/10.1186/1471-2407-13-477

Ridner, S. H., Dietrich, M. S., & Kidd, N. (2011). Breast cancer treatment-related lymphedema self-care: Education, practices, symptoms, and quality of life. Supportive Care in Cancer, 19(5), 631–637. https://doi.org/10.1007/s00520-010-0870-5

Rosen, G. P., Nguyen, H.-T., & Shaibi, G. Q. (2013). Metabolic syndrome in pediatric cancer survivors: A mechanistic review. Pediatric Blood & Cancer, 60(12), 1922–1928. https://doi.org/10.1002/pbc.24703

Saha, S. K., Parachoniak, C. A., Ghanta, K. S., Fitamant, J., Ross, K. N., Najem, M. S., … Bardeesy, N. (2014). Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer. Nature, 513, 110–114. https://doi.org/10.1038/nature13441

Schmitz, K. H., Troxel, A. B., Dean, L. T., DeMichele, A., Brown, J. C., Sturgeon, K., … Sarwer, D. B. (2019). Effect of home-based exercise and weight loss programs on breast cancer–related lymphedema outcomes among overweight breast cancer survivors: The WISER Survivor randomized clinical trial. JAMA Oncology, 5(11), 1605. https://doi.org/10.1001/jamaoncol.2019.2109

Shaitelman, S. F., Cromwell, K. D., Rasmussen, J. C., Stout, N. L., Armer, J. M., Lasinski, B. B., & Cormier, J. N. (2015). Recent progress in the treatment and prevention of cancer-related lymphedema. CA: A Cancer Journal for Clinicians, 65(1), 55–81. https://doi.org/10.3322/caac.21253

Siegel, R. L., Miller, K. D., & Jemal, A. (2019). Cancer statistics, 2019. CA: A Cancer Journal for Clinicians, 69(1), 7–34. https://doi.org/10.3322/caac.21551

Sitjar, P. H. S., Tan, S. Y., Wong, M., Li, J., Jalil, R. B. A., Aw, H., Lim, E. H., & Goh, J. (2024). Combined aero-bic and strength exercise training on biological ageing in Singaporean breast cancer patients: Protocol for the Breast Cancer Exercise Intervention (BREXINT) Pilot Study. GeroScience. https://doi.org/10.1007/s11357-024-01145-9

Schardt, C., Adams, M. B., Owens, T., Keitz, S., & Fontelo, P. (2007). Utilización del marco PICO para me-jorar la búsqueda de preguntas clínicas en PubMed. BMC Medical Informatics and Decision Ma-king, 7(1), 16. https://doi.org/10.1186/1472-6947-7-16

Soriano-Maldonado, A., Díez-Fernández, D. M., Esteban-Simón, A., Rodríguez-Pérez, M. A., Artés-Rodríguez, E., Casimiro-Artés, M. A., … Casimiro-Andújar, A. J. (2023). Effects of a 12-week su-pervised resistance training program, combined with home-based physical activity, on physical fitness and quality of life in female breast cancer survivors: The EFICAN randomized controlled trial. Journal of Cancer Survivorship, 17(5), 1371–1385. https://doi.org/10.1007/s11764-022-01192-1

Stone, M. H., Hornsby, W. G., Suarez, D. G., Duca, M., & Pierce, K. C. (2022). Training specificity for ath-letes: Emphasis on strength-power training. Journal of Functional Morphology and Kinesiology, 7(4), 102. https://doi.org/10.3390/jfmk7040102

Sultana, R. N., Sabag, A., Keating, S. E., & Johnson, N. A. (2019). The effect of low-volume high-intensity interval training on body composition and cardiorespiratory fitness: A systematic review and meta-analysis. Sports Medicine, 49(11), 1687–1721. https://doi.org/10.1007/s40279-019-01167-w

Sweeney, F. C., Demark-Wahnefried, W., Courneya, K. S., Sami, N., Lee, K., Tripathy, D., … Dieli-Conwright, C. M. (2019). Aerobic and resistance exercise improves shoulder function in women who are overweight or obese and have breast cancer: A randomized controlled trial. Physical Therapy, 99(10), 1334–1345. https://doi.org/10.1093/ptj/pzz096

Taylor, R. S., Brown, A., Ebrahim, S., Jolliffe, J., Noorani, H., Rees, K., … Oldridge, N. (2004). Exercise-based rehabilitation for patients with coronary heart disease: Systematic review and meta-analysis of randomized controlled trials. The American Journal of Medicine, 116(10), 682–692. https://doi.org/10.1016/j.amjmed.2004.01.009

Torre, L. A., Siegel, R. L., Ward, E. M., & Jemal, A. (2016). Global cancer incidence and mortality rates and trends—An update. Cancer Epidemiology, Biomarkers & Prevention, 25(1), 16–27. https://doi.org/10.1158/1055-9965.EPI-15-0578

Turner, R. R., Steed, L., Quirk, H., Greasley, R. U., Saxton, J. M., Taylor, S. J. C., … Bourke, L. (2018). Interventions for promoting habitual exercise in people living with and beyond cancer. Cochrane Database of Systematic Reviews, 2018(9). https://doi.org/10.1002/14651858.CD010192.pub3

Uth, J., Fristrup, B., Sørensen, V., Helge, E. W., Christensen, M. K., Kjærgaard, J. B., … Krustrup, P. (2020). Exercise intensity and cardiovascular health outcomes after 12 months of football fitness training in women treated for stage I–III breast cancer: Results from the Football Fitness After Breast Cancer (ABC) randomized controlled trial. Progress in Cardiovascular Diseases, 63(6), 792–799. https://doi.org/10.1016/j.pcad.2020.08.002

Valle-Solís, A. E., Miranda-Aguirre, A. P., Mora-Pérez, J., Pineda-Juárez, J. A., Gallardo-Valencia, L. E., San-tana, L., … Cárdenas-Cárdenas, E. (2019). Supervivencia en cáncer de mama por subtipo me-diante inmunohistoquímica: Un estudio retrospectivo. Gaceta Médica de México, 155(91). https://doi.org/10.24875/gmm.19005133

Wang, T.-C., Chen, P.-L., Liao, W.-C., & Tsai, I.-C. (2023). Differential impact of exercises on quality-of-life improvement in breast cancer survivors: A network meta-analysis of randomized controlled trials. Cancers, 15(13), 3380. https://doi.org/10.3390/cancers15133380

Wang, X. S., & Woodruff, J. F. (2015). Cancer-related and treatment-related fatigue. Gynecologic Oncol-ogy, 136(3), 446–452. https://doi.org/10.1016/j.ygyno.2014.10.013

Waitkus, M. S., Diplas, B. H., & Yan, H. (2018). Biological role and therapeutic potential of IDH mutations in cancer. Cancer Cell, 34(2), 186–195. https://doi.org/10.1016/j.ccell.2018.07.005

Wernhart, S., & Rassaf, T. (2024). Relevance of cardiovascular exercise in cancer and cancer therapy-related cardiac dysfunction. Current Heart Failure Reports, 21(3), 238–251. https://doi.org/10.1007/s11897-024-00662-0

Weis, J. (2011). Cancer-related fatigue: Prevalence, assessment and treatment strategies. Expert Review of Pharmacoeconomics & Outcomes Research, 11(4), 441–446. https://doi.org/10.1586/erp.11.44

Williams, M. A., Haskell, W. L., Ades, P. A., Amsterdam, E. A., Bittner, V., Franklin, B. A., … Stewart, K. J. (2007). Resistance exercise in individuals with and without cardiovascular disease: 2007 up-date: A scientific statement from the American Heart Association Council. Circulation, 116(5), 572–584. https://doi.org/10.1161/CIRCULATIONAHA.107.185214

Yasutake, K., Kumahara, H., Shiose, K., Kawano, M., & Michishita, R. (2024). Association between grip strength and electrical properties measured by bioimpedance spectroscopy in women with dementia aged 77 to 97 years living in group homes. Medicine International, 4(4). https://doi.org/10.3892/mi.2024.157

Zhang, Y., Zhou, Y., Mao, F., Yao, R., & Sun, Q. (2020). Ki‐67 index, progesterone receptor expression, histologic grade and tumor size in predicting breast cancer recurrence risk: A consecutive co-hort study. Cancer Communications, 40(4), 181–193. https://doi.org/10.1002/cac2.12024

Zmorzynski, S., Kimicka-Szajwaj, A., Szajwaj, A., Czerwik-Marcinkowska, J., & Wojcierowski, J. (2024). Genetic changes in mastocytes and their significance in mast cell tumor prognosis and treat-ment. Genes, 15(1), 137. https://doi.org/10.3390/genes15010137

Descargas

Publicado

2025-05-23

Cómo citar

Tauda, M., Cruzat Bravo, E., & Suárez Rojas, F. (2025). Beneficios del ejercicio supervisado en la rehabilitación de pacientes oncológicos: una revisión sistemática . Retos, 68, 765–789. https://doi.org/10.47197/retos.v68.110146

Número

Sección

Revisiones teóricas sistemáticas y/o metaanálisis

Artículos más leídos del mismo autor/a

<< < 1 2