Asociación del polimorfismo GLY482SER del gen PGC-1α con el rendimiento aeróbico y la fuerza muscular
DOI:
https://doi.org/10.47197/retos.v68.112827Palabras clave:
Gly482Ser, rendimiento aeróbico, polimorfismo de PGC-1α, test de rendimiento físico, adultos jóvenes.Resumen
Introducción: El gen del coactivador del receptor gamma 1-alfa activado por el proliferador de peroxisomas (PGC-1α) tiene un polimorfismo conocido como Gly482Ser que se ha asociado con la capacidad aeróbica.
Objetivo. Explorar la asociación del polimorfismo Gly482Ser del gen PGC-1α con el rendimiento aeróbico y fuerza en adultos jóvenes.
Métodos. Un estudio de corte transversal comprendió 106 participantes. El polimorfismo Gly482Ser se determinó utilizando la técnica RFLP-PCR. Se administraron evaluaciones físicas estandarizadas para capacidad aeróbica y fuerza muscular.
Resultados. El genotipo homocigoto Gly482 demostró un mejor rendimiento físico evaluado por la prueba de caminata de 6 minutos (6MWT), y una mejor recuperación de frecuencia cardíaca. Los hombres homocigotos Gly482 lograron una mayor distancia de caminata. Las mujeres tuvieron un mayor consumo de oxígeno durante la prueba de Astrand. No se observaron diferencias significativas en el índice de Ruffier. En la fuerza muscular evaluada a través del test de flexiones, las mujeres con el genotipo Gly482 se encontraron en desventaja, sin diferencias en fuerza de agarre manual y fuerza isométrica máxima. Para los hombres, no se observaron diferencias estadísticamente significativas en la fuerza muscular.
Discusión. Los resultados son consistentes con informes previos en los que el alelo Gly482 muestra una asociación con el rendimiento aeróbico, mientras que el alelo Ser482 se ha asociado con la fuerza y potencia muscular.
Conclusiones. El polimorfismo Gly482Ser del gen PGC-1α se asocia con variaciones en el rendimiento físico, en donde el genotipo Gly482 demuestra un rendimiento superior en evaluaciones de capacidad aeróbica entre adultos jóvenes.
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- Se permite y se anima a los autores a difundir sus trabajos electrónicamente (por ejemplo, en repositorios institucionales o en su propio sitio web) antes y durante el proceso de envío, ya que puede dar lugar a intercambios productivos, así como a una citación más temprana y mayor de los trabajos publicados (Véase The Effect of Open Access) (en inglés).
Esta revista sigue la "open access policy" de BOAI (1), apoyando los derechos de los usuarios a "leer, descargar, copiar, distribuir, imprimir, buscar o enlazar los textos completos de los artículos".
(1) http://legacy.earlham.edu/~peters/fos/boaifaq.htm#openaccess
