Eficacia de la movilización de Mulligan frente a los ejercicios propioceptivos en la osteoartritis de rodilla: un ensayo clínico aleatorizado

Autores/as

  • Muhammad Atif Khan Lincoln University College, Malaysia
  • Satheesh Babu Natarajan Lincoln University College, Malaysia
  • Muhammad Ahmed Azmi Al-Tibri Medical College, Isra University Karachi Campus
  • Hira Islam Al Hamd Institute of Physiotherapy & Health Sciences
  • Muhammad Asif Department of Rehabilitation & Health Sciences, Nazeer Hussain University
  • Mahtab Ahmed Mukhtar Patafi Tahseen Ahmed Cheema Institute, Bahawalpur
  • Nasir Mehmood Department of Physical Therapy, The Islamia University of Bahawalpur
  • Nigar Begum Al Hamd Institute of Physiotherapy & Health Sciences

DOI:

https://doi.org/10.47197/retos.v75.118251

Palabras clave:

Osteoartritis de rodilla, movilización de Mulligan, ejercicios propioceptivos, fisioterapia, NPRS, KOOS, ensayo clínico aleatorizado

Resumen

Antecedentes. La osteoartritis de rodilla (OAR) es un trastorno ortopédico común que provoca dolor crónico, limita la movilidad y reduce la calidad de vida en general. Aunque la eficacia de la terapia con ejercicio está respaldada por evidencia empírica, la efectividad relativa de la Movilización con Movimiento de Mulligan (MMT), en comparación con el entrenamiento propioceptivo, aún no ha sido claramente establecida.

Objetivo. El objetivo del presente estudio fue comparar los efectos de la MMT, los ejercicios propioceptivos (PEG) y la fisioterapia estándar en personas con OAR, en relación con el dolor y el estado funcional.

Métodos. Se llevó a cabo un ensayo clínico aleatorizado con 60 participantes (edad ≥ 40 años) durante un período de 10 semanas. Los participantes fueron asignados a los grupos de MMT, PEG o fisioterapia convencional (grupo control). La intensidad del dolor (NPRS) y la función de la rodilla (puntuación total KOOS) se evaluaron al inicio del estudio y en la 4.ª, 8.ª y 10.ª semana. Se utilizó un ANOVA de medidas repetidas con comparaciones por pares ajustadas mediante Bonferroni.

Resultados. Se observaron mejoras estadísticamente significativas en todos los grupos de intervención (p < 0.001). La mayor reducción del dolor y la máxima mejora funcional se encontraron en el grupo MMT. El grupo PEG mostró un grado intermedio de mejoría, mientras que la fisioterapia convencional presentó el menor tamaño del efecto. Los tamaños del efecto fueron más altos en el grupo MMT (NPRS η² = 0.624; KOOS η² = 0.387).

Conclusión. En pacientes con osteoartritis de rodilla, la Movilización con Movimiento de Mulligan demostró ser superior a los ejercicios propioceptivos y a la fisioterapia tradicional para reducir el dolor y mejorar la función de la rodilla. Estos resultados respaldan el uso de la MMT como una modalidad conservadora de primera elección, ofreciendo a los clínicos una alternativa potente y eficaz para lograr mejores resultados en los pacientes.

Referencias

Abbas, F., Taher, H., Bagheri, Z., Ashnagar, S., & Jalaei, S. (2022). Comparison of effects of Mulligan tech-niques and muscle energy technique on pain and function in knee osteoarthritis. Journal of Mo-dern Rehabilitation. https://doi.org/10.18502/jmr.v17i1.11302

Adhama, A. I., Akindele, M. O., & Ibrahim, A. A. (2022). A pilot randomized trial of different weekly ap-plications of kinesthesia, balance and agility exercise program for individuals with knee osteo-arthritis. Jundishapur Journal of Health Sciences, 14(2).

Aliyah, U., Qureshi, A., Saeed, A., Hameed, M., Arshad, A., Khalid, H., Khawar, K., & Rehman, A. U. (2023). Comprehensive meta-analysis of Mulligan’s mobilization with movement in knee osteoarthri-tis: Immediate and short-term efficacy on pain, function, and emotional well-being. Interna-tional Journal of Membrane Science and Technology. https://doi.org/10.15379/ijmst.v10i3.3369

Aman, J. E., Elangovan, N., Yeh, I. L., & Konczak, J. (2015). The effectiveness of proprioceptive training for improving motor function: A systematic review. Frontiers in Human Neuroscience, 8, 1075. https://doi.org/10.3389/fnhum.2014.01075

Anwer, S., Alghadir, A., Zafar, H., & Brismée, J. M. (2018). Effects of orthopaedic manual therapy in knee OA: A systematic review and meta-analysis. Physiotherapy, 104(3), 264–276. https://doi.org/10.1016/j.physio.2018.05.003

Bartholdy, C., Juhl, C., Christensen, R., Lund, H., Zhang, W., & Henriksen, M. (2017). The role of muscle strengthening in exercise therapy for knee osteoarthritis: A systematic review and meta-regression analysis of randomized trials. Seminars in Arthritis and Rheumatism, 47, 921–927. https://doi.org/10.1016/j.semarthrit.2017.01.003

Bhagat, M., Neelapala, Y. R., & Gangavelli, R. (2020). Immediate effects of Mulligan’s techniques on pain and functional mobility in individuals with knee osteoarthritis: A randomized control trial. Physiotherapy Research International, 25(1), e1812. https://doi.org/10.1002/pri.1812

Brosseau, L., Taki, J., Desjardins, B., Thevenot, O., Fransen, M., Wells, G. A., et al. (2017). The Ottawa Pan-el clinical practice guidelines for the management of knee osteoarthritis. Part three: Aerobic ex-ercise programs. Clinical Rehabilitation, 31(5), 612–624. https://doi.org/10.1177/0269215517691083

Buke, M., Ünver, F., Sekeroz, S., & Öztekin, S. N. (2024). Effectiveness of Mulligan mobilization tech-nique and core stabilization exercises in female patients with knee osteoarthritis: A randomized controlled single-blind study. Journal of Manipulative and Physiological Therapeutics, 47(1–4), 33–44. https://doi.org/10.1016/j.jmpt.2024.08.012

Chen, X., Yu, D., Lin, Y., Chen, P., Shao, B., & Wu, F. (2024). Effects of joint mobilization on pain, range of motion, and function in patients with knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials. medRxiv. https://doi.org/10.1101/2024.11.10.24317074

Cho, Y., Kim, M. Y., & Lee, W. (2015). Effect of proprioceptive training on foot posture, lower limb alignment, and knee adduction moment in patients with degenerative knee osteoarthritis: A randomized controlled trial. Journal of Physical Therapy Science, 27(2), 371–374.

Demirci, S., Kinikli, G. I., Callaghan, M. J., & Tunay, V. B. (2017). Comparison of short-term effects of mo-bilization with movement and kinesiotaping on pain, function, and balance in patellofemoral pain. Acta Orthopaedica et Traumatologica Turcica, 51(6), 442–447. https://doi.org/10.1016/j.aott.2017.05.007

Elbasti, M. S., & Yentür, S. B. (2025). Immediate effects of Mulligan mobilization and taping on pain and functional status in patients with knee osteoarthritis. Annals of Medical Research, 32(3), 92–96. https://doi.org/10.5455/annalsmedres.2024.11.241

Euasobhon, P., Atisook, R., Bumrungchatudom, K., Zinboonyahgoon, N., Saisavoey, N., & Jensen, M. P. (2022). Reliability and responsivity of pain intensity scales in individuals with chronic pain. Pain, 163(12), e1184–e1191.

Fransen, M., McConnell, S., Harmer, A. R., Van der Esch, M., Simic, M., & Bennell, K. L. (2015). Exercise for osteoarthritis of the knee: A Cochrane database of systematic reviews. British Journal of Sports Medicine, 49(24), 1554–1557. https://doi.org/10.1136/bjsports-2015-095424

Gayretli Atan, S., Pehlivan, E., & Bağçacı, S. (2025). Evaluation of the effectiveness of proprioceptive training according to radiological stages in patients with knee osteoarthritis. Medicina (Kaunas), 61(3), 546. https://doi.org/10.3390/medicina61030546

Ghafoor, F., Iqbal, M. A., Nasir, M., Shakoor, A., Seemal, P., & Sabir, I. (2023). Comparison of the effec-tiveness of exercise therapy vs Mulligan’s mobilization with movement on pain and daily living activities in household females with knee osteoarthritis. Biomedical Journal of Scientific & Technical Research, 51, 42156–42162. https://doi.org/10.26717/BJSTR.2023.51.008031

Gohil, M., & Shukla, Y. (2020). Effect of proprioceptive training using biofeedback (Equiboard) on pain, function and proprioception in osteoarthritic knee. International Journal of Scientific and Healthcare Research, 5(1), 232–237.

Habib, Z., Ambreen, F., Chaudhary, W. A., Ejaz, B., Awan, K. M., Arif, K., & Mohsin, A. (2025). Effective-ness of dry needling with or without Mulligan two-leg rotation technique on pain, range of mo-tion, and joint dysfunction in knee osteoarthritis. Insights Journal of Health & Rehabilitation, 3(2), 581–589. https://doi.org/10.71000/sxb4pf37

Hauk, L. (2014). Treatment of knee osteoarthritis: A clinical practice guideline from the AAOS. Ameri-can Family Physician, 89(11), 918–920.

Hifza, A., Arif, N., Kanwal, N., Tahir, H., Akmal, I., Hussain, S., & Munawar, M. I. (2023). Screening of ther-apeutic potentials of proprioceptive exercises and topical glucosamine sulfate on pain and func-tional disability in knee osteoarthritis. Tropical Journal of Pharmaceutical Research. https://doi.org/10.4314/tjpr.v21i11.25

Hing, W., Hall, T., Rivett, D., Vicenzino, B., & Mulligan, B. (2015). The Mulligan concept of manual thera-py: Textbook of techniques. Elsevier.

İnce, B., Göksel Karatepe, A., Akçay, S., & Kaya, T. (2023). The efficacy of balance and proprioception exercises in female patients with knee osteoarthritis: A randomized controlled study. Clinical Rehabilitation, 37(1), 60–71. https://doi.org/10.1177/02692155221111929

Jadhav, V. S., & Anap, D. B. (2019). Effectiveness of Mulligan mobilization versus McKenzie exercises in knee osteoarthritis: A single-blind randomized controlled trial. Physiotherapy and Rehabilita-tion, 4, 177.

Jain, P., & Shinde, S. (2025). Effect of aquatic resistance, balance, and proprioception training on lower limb muscle performance in bilateral knee osteoarthritis. Journal of Musculoskeletal Surgery and Research, 9(1), 104–111. https://doi.org/10.25259/JMSR_230_2024

Jeong, H. S., Lee, S. C., Jee, H., Song, J. B., Chang, H. S., & Lee, S. Y. (2019). Proprioceptive training and out-comes of patients with knee osteoarthritis: A meta-analysis of randomized controlled trials. Journal of Athletic Training, 54(4), 418–428. https://doi.org/10.4085/1062-6050-329-17

Jeong, J. H., Kim, J. G., Lee, Y. J., & Lee, D. Y. (2019). The effects of proprioceptive exercise and taping on knee joint position sense and balance ability in patients with knee OA. Journal of Physical Ther-apy Science, 31(6), 438–441.

Ju, S. B., Park, G. D., & Kim, S. S. (2015). Effects of proprioceptive circuit exercise on knee joint pain and muscle function in patients with knee osteoarthritis. Journal of Physical Therapy Science, 27(4), 2439–2441. https://doi.org/10.1589/jpts.27.2439

Kiran, A., Ijaz, M. J., Qamar, M. M., Basharat, A., Rasul, A., & Ahmed, W. (2018). Comparison of efficacy of Mulligan’s mobilization with Maitland mobilization along with conventional therapy in the pa-tients with knee osteoarthritis: A randomized clinical trial. Libyan International Medical Uni-versity Journal, 3(1), 26–30. https://doi.org/10.4103/LIUJ.LIUJ_12_18

Kirthika, V., Sudhakar, S., Padmanabhan, K., Ramachandran, S., & Kumar, M. (2018). Efficacy of com-bined proprioceptive exercises and conventional physiotherapy in patients with knee osteoar-thritis: A double-blinded two-group pretest–posttest design. Journal of Orthopaedic Trauma-tology and Rehabilitation, 10, 94–97. https://doi.org/10.4103/jotr.jotr_40_17

Kong, H., Wang, X. Q., & Zhang, X. A. (2022). Exercise for osteoarthritis: A literature review of pathology and mechanism. Frontiers in Aging Neuroscience, 14, 854026. https://doi.org/10.3389/fnagi.2022.854026

Kulkarni, M., Agrawal, R., Khan, T., & Vejlani, F. (2019). Effect of proprioceptive exercises on knee joint position sense and balance in patients with knee osteoarthritis. Physiotherapy & Physical Edu-cation, 4, 20–24.

Lalnunpuii, A., Sarkar, B., Alam, S., Equebal, A., & Biswas, A. (2017). Efficacy of Mulligan mobilization compared to Maitland mobilization in females with knee osteoarthritis: A double-blind ran-domized controlled trial. International Journal of Therapies and Rehabilitation Research, 6(2), 37–40. https://doi.org/10.5455/ijtrr.000000241

Li, L. L., Hu, X. J., Di, Y. H., & Jiao, W. (2022). Effectiveness of Maitland and Mulligan mobilization meth-ods for adults with knee osteoarthritis: A systematic review and meta-analysis. World Journal of Clinical Cases, 10(3), 954–962. https://doi.org/10.12998/wjcc.v10.i3.954

Lin, Y., Yu, D., Chen, X., Chen, P., Chen, N., Shao, B., et al. (2025). Effects of proprioceptive exercise for knee osteoarthritis: A systematic review and meta-analysis. Frontiers in Rehabilitation Scienc-es, 6, 1596966. https://doi.org/10.3389/fresc.2025.1596966

Ljubojevic, A., Popovic, B., Bijelic, S., & Jovanovic, S. (2020). Proprioceptive training in dance sport: Effects on agility skills. Turkish Journal of Kinesiology, 6(3), 109–117.

Madhumita, R., Ramana, K., Anitha, A., & Kamalakannan, M. (2024). Effect of Mulligan techniques on pain reduction and improving functional activity of shoulder among periarthritis shoulder indi-viduals. Indian Journal of Physiotherapy and Occupational Therapy, 18. https://doi.org/10.37506/f5zcrm83

May, J., Krzyzanowicz, R., Nasypany, A., Baker, R., & Seegmiller, J. (2015). Mulligan concept use and clin-ical profile from the perspective of American certified Mulligan practitioners. Journal of Sport Rehabilitation, 24(4), 337–341. https://doi.org/10.1123/jsr.2013-0119

Moitra, M., & Sharma, S. (2016). Effectiveness of proprioceptive training programme on joint position sense and balance in patients with knee osteoarthritis: A randomized controlled trial. Journal of Disability Studies, 3(1), 5–7.

Mostamand, J., Adeli, M., Ahmadi, H., & Hassanzadeh, A. (2023). Effect of Mulligan mobilization tech-nique on static and dynamic balance in moderate to severe knee osteoarthritis: A randomized controlled clinical trial. Journal of Rehabilitation Sciences Research, 10(1), 25–30.

Nazir, S. N., Ali, S. S., & Akhtar, S. (2020). Effectiveness of Mulligan joint mobilizations and trunk stabili-zation exercises versus isometric knee strengthening in the management of knee osteoarthritis: Study protocol for randomized controlled trial. medRxiv. https://doi.org/10.1101/2020.05.03.20089276

Phatama, K. Y., Aziz, A., Bimadi, M. H., Oktafandi, I. G. N. A. A., Cendikiawan, F., & Mustamsir, E. (2021). Knee injury and osteoarthritis outcome score: Validity and reliability of an Indonesian version. Ochsner Journal, 21(1), 63–67.

Prabhakar, A. J., Joshua, A. M., Prabhu, S., & Kamat, Y. D. (2020). Effectiveness of proprioceptive training versus conventional exercises on postural sway in early knee osteoarthritis: RCT protocol. In-ternational Journal of Surgery Protocols, 24, 6–11. https://doi.org/10.1016/j.isjp.2020.09.002

Qureshi, A. U., Saeed, A., Hameed, M., et al. (2023). Comprehensive meta-analysis of Mulligan’s mobiliza-tion with movement in knee osteoarthritis: Immediate and short-term efficacy on pain, func-tion, and emotional well-being. International Journal of Membrane Science and Technology, 10(3), 3397–3406. https://doi.org/10.15379/ijmst.v10i3.3369

Rangparia, F., & Singh, A. K. (2025). Comparison of effect of McKenzie exercise and Mulligan with movement on ROM and physical function in KOA: Randomized control trial. International Jour-nal of Physical Therapy Research Studies, 4(2).

Rao, R. V., Balthillaya, G., Prabhu, A., & Kamath, A. (2018). Immediate effects of Maitland mobilization versus Mulligan MWM in osteoarthritis knee: Randomized crossover trial. Journal of Bodywork and Movement Therapies, 22(3), 572–579. https://doi.org/10.1016/j.jbmt.2017.09.011

Rao, D. D., Chaudhry, H., Kumar, S. P., & Sharan, D. (2018). Comparative effectiveness of Mulligan's mo-bilization and Maitland's mobilization in knee osteoarthritis: A randomized controlled trial. Journal of Bodywork and Movement Therapies, 22(3), 817–823.

Razek, R. A., & Shenouda, M. M. (2014). Efficacy of Mulligan’s mobilization with movement on pain, disability, and range of motion in patients with knee osteoarthritis: Randomized controlled pi-lot study. Indian Journal of Physiotherapy and Occupational Therapy, 8(1), 242–246.

Richhariya, N., Mudaliar, S., & Kumar, D. V. (2023). Efficacy of proprioceptive exercises and core strengthening with conventional physiotherapy on pain and quality of life in knee osteoarthri-tis. International Journal of Scientific and Healthcare Research, 8(1), 267–272. https://doi.org/10.52403/ijshr.2023013

Roos, E. M. (2024). 30 years with the Knee Injury and Osteoarthritis Outcome Score (KOOS). Osteoar-thritis and Cartilage, 32(4), 421–429.

Rosadi, R., Wu, P. T., You, Y. L., Kuo, L. C., & Lin, C. F. (2023). Effectiveness of combined exercise and physiotherapy intervention in improving functional activity of patients with knee osteoarthritis in Muslim prayer movements. Journal of Medical and Biological Engineering, 43(2), 125–134.

Sarallahi, M., Amiri, A., & Sarafzadeh, J. (2020). The effect of quadriceps kinesio tape on functional disa-bility, pain, and knee joint position sense in knee osteoarthritis patients. Journal of Clinical Phys-iotherapy, 62(3), 15–18.

Shaikh, N., Bukhsh, N., Farooq, A., & Rathore, F. A. (2024). Efficacy of Mulligan joint mobilizations and trunk stabilization exercises versus isometric knee strengthening in knee osteoarthritis: A ran-domized controlled trial. BMC Sports Science, Medicine & Rehabilitation. https://doi.org/10.1186/s13102-024-00893-7

Sheikhhoseini, R., Dadfar, M., Shahrbanian, S., Piri, H., & Salsali, M. (2023). The effects of exercise train-ing on knee repositioning sense in people with knee osteoarthritis: Systematic review and meta-analysis of clinical trials. BMC Musculoskeletal Disorders, 24(1), 592. https://doi.org/10.1186/s12891-023-06712-3

Sobhani, V., Hashemi, S. E., Mir, S. M., & Ghorbanpour, A. (2024). Impact of proprioceptive exercises on pain, balance, and fall risk in the elderly with knee osteoarthritis: A randomized clinical trial. Cureus, 16(10), e70885.

Solanki, D., & Kage, V. (2015). Effectiveness of medial Mulligan glide versus internal rotation Mulligan glide in KOA: Randomized clinical trial. Revista Română de Kinetoterapie, 21(35).

Stathopoulos, N., Dimitriadis, Z., & Koumantakis, G. A. (2019). Effectiveness of Mulligan’s mobilization with movement techniques in peripheral joints: A systematic review with meta-analysis be-tween 2008–2017. Physiotherapy, 105(1), 1–9. https://doi.org/10.1016/j.physio.2018.08.005

Subbiah, S. (2023). Effectiveness of Mulligan’s mobilization with movement on pain pressure threshold and functional ability in subjects with knee osteoarthritis. International Journal of Life Science and Pharma Research, 13(4), 182–192. https://doi.org/10.22376/ijlpr.2023.13.4.l182-l192

Subramanian, M. B., & Rajesh, P. (2021). Effect of Mulligan mobilization on proprioception in osteoar-thritis of the knee joint: Systematic review. Journal of Pharmaceutical Research International, 33(60B), 1027–1034. https://doi.org/10.9734/jpri/2021/v33i60B34709

Tabassum, H., Qaiser, F., Bhatti, H. N., et al. (2024). Efficacy of Mulligan MWM along with conventional physical therapy in knee osteoarthritis. Journal of Health Rehabilitation Research, 4(1), 1349–1354. https://doi.org/10.61919/jhrr.v4i1.603

Ughreja, R. A., & Shukla, Y. U. (2017). Mulligan’s mobilization with movement relieves pain and im-proves functional status in osteoarthritis knee. International Journal of Physiotherapy, 4(2), 132–138*. https://doi.org/10.15621/ijphy/2017/v4i2/141954

Vamsidhar, N., Reddy, R. S., Thiruppathi, A., Ravindran, B., & Sivakumar, B. (2017). Effectiveness of pro-prioceptive training and strengthening exercises in osteoarthritis of knee. Journal of Medical Science and Clinical Research, 5, 23352–23356. https://doi.org/10.18535/jmscr/v6i1.02

Vishnupriya, R. (2017). A comparative study of balance training with foam balance activity versus pro-prioceptive exercise in the management of osteoarthritis knee [Master’s thesis]. https://doi.org/10.36678/IJMAES.2024.V10I02.004

Viswas, R., Ramachandran, R., Anantkumar, V. K., & Mathew, L. (2021). Proprioceptive training and its impact on knee OA: A review of current evidence. Open Access Rheumatology: Research and Reviews, 13, 21–31.

Vrushali, S., Jadhav, D. B., & Anap, D. (2019). Effectiveness of Mulligan mobilization versus McKenzie exercises in knee osteoarthritis: A single-blind randomized controlled trial.

Wang, Y., Wu, Z., Chen, Z., Ye, X., Chen, G., & Yang, J. (2021). Proprioceptive training for knee osteoar-thritis: A systematic review and meta-analysis of randomized controlled trials. Frontiers in Medicine, 8, 699921. https://doi.org/10.3389/fmed.2021.699921

Weleslassie, G. G., Temesgen, M. H., Alamer, A., Tsegay, G. S., Hailemariam, T. T., & Melese, H. (2021). Effectiveness of mobilization with movement on the management of knee osteoarthritis: A sys-tematic review of randomized controlled trials. Pain Research and Management, 2021, 8815682. https://doi.org/10.1155/2021/8815682

Westad, K., Tjoestolvsen, F., & Hebron, C. (2019). The effectiveness of Mulligan’s mobilization with movement on peripheral joints in musculoskeletal conditions: A systematic review. Musculo-skeletal Science and Practice, 39, 157–163. https://doi.org/10.1016/j.msksp.2019.03.006

Zain, N., Omar, T., & Younis, J. (2020). Effect of self-care model intervention on quality of life of knee OA patients. Research and Review Health Care Journal, 2(2), 1–9.

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02-02-2026

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Revisiones teóricas sistemáticas y/o metaanálisis

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Khan, M. A., Natarajan, S. B., Azmi, M. A., Islam, H., Asif, M., Patafi, M. A. M., Mehmood, N., & Begum, N. (2026). Eficacia de la movilización de Mulligan frente a los ejercicios propioceptivos en la osteoartritis de rodilla: un ensayo clínico aleatorizado. Retos, 75, 963-976. https://doi.org/10.47197/retos.v75.118251