Core stabilization with biofeedback-guided quadriceps–hamstring strengthening in knee osteoarthritis: a randomized trial

Authors

  • Advendila Margaretha Artz Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hasanuddin University
  • Anshory Sahlan Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hasanuddin University https://orcid.org/0009-0007-4294-9782
  • Husnul Mubarak Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hasanuddin University https://orcid.org/0000-0002-1404-2960
  • Andi Alfian Zainuddin Department of Public Health Sciences, Faculty of Medicine, Hasanuddin University https://orcid.org/0000-0003-4590-6407
  • Yose Waluyo Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hasanuddin University
  • Nuralam Sam Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hasanuddin University

DOI:

https://doi.org/10.47197/retos.v80.119290

Keywords:

core stabilization, exercise therapy, functional outcome, knee osteoarthritis, randomized controlled trial

Abstract

Introduction: Appropriate exercise therapies are still being investigated for primary knee osteoarthritis, which greatly contributes to chronic pain and functional impairment in older adults.
Objective: The purpose of this study was to evaluate the effectiveness of adding core stability to biofeedback-assisted quadriceps-hamstring strengthening for individuals with primary osteoarthritis of the knee.

Methodology: Participants between the ages of 50 and 65 participated in a parallel-group, randomised controlled study conducted at a single location. For six weeks, participants participated in twice-weekly supervised exercise sessions. The Western Ontario and McMaster Universities Osteoarthritis Index was used to assess functional status at baseline and on a weekly basis, while the Numeric Rating Scale was used to measure the intensity of pain.

Results: Forty participants were randomized, with 39 completing the study. Both groups shown gradual enhancements in pain and functionality. Significant between-group differences in pain emerged from week four, and by week six, the combined intervention group showed lower pain levels compared to the strengthening-only group. Functional outcomes also showed significant differences at week six, favoring the combined intervention. Statistical analysis revealed significant time-by-group interactions for both pain and functional measures.

Discussion: The addition of core stabilization appears to enhance the effectiveness of strengthening exercises, possibly by improving neuromuscular control and joint stability.

Conclusions: Incorporating core stabilization into strengthening programs provides additional short-term benefits in reducing pain and improving function in individuals with primary knee osteoarthritis.

References

Achens, J. T., Victor, V. S. R., & Joseph, J. K. (2022). Early activation of quadriceps with pressure biofeedback for the prevention of arthrogenic muscle inhibition following lower limb orthope-dic surgeries: A proof-of-concept clinical trial. Journal of Chiropractic Medicine, 21(4), 296–304. https://doi.org/10.1016/j.jcm.2022.05.005

Al-Johani, A., Kachanathu, S. J., Hafez, A. R., Al-Ahaideb, A., Algarni, A., Alroumi, A. M., & Alenazi, A. (2014). Comparative study of hamstring and quadriceps strengthening treatments in the mana-gement of knee osteoarthritis. Journal of Physical Therapy Science, 26, 817–820.

Bannuru, R. R., Osani, M. C., Vaysbrot, E. E., Arden, N. K., Bennell, K., Bierma-Zeinstra, S. M. A., Kraus, V. B., Lohmander, L. S., Abbott, J. H., Bhandari, M., Blanco, F. J., Espinosa, R., Haugen, I. K., Lin, J., Mandl, L. A., Moilanen, E., Nakamura, N., Snyder-Mackler, L., Trojian, T., … McAlindon, T. E. (2019). OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthri-tis. Osteoarthritis and Cartilage, 27(11), 1578–1589. https://doi.org/10.1016/j.joca.2019.06.011

Bennell, K., Hinman, R. S., Wrigley, T. V., Creaby, M. W., & Hodges, P. (2011). Exercise and osteoarthritis: Cause and effects. Comprehensive Physiology, 1(4), 1943–2008. https://doi.org/10.1002/j.2040-4603.2011.tb00377.x

Christensen, J. C., Jakiela, J. T., & White, D. K. (2022). Factors associated with trajectories of physical activity over 8 years in knee osteoarthritis. European Journal of Rheumatology, 10(1), 1–7. https://doi.org/10.5152/eurjrheum.2022.21155

Draper, V., Ballard, L., & Snyder-Mackler, L. (1991). Electrical stimulation versus electromyographic biofeedback in the recovery of quadriceps femoris muscle function following anterior cruciate ligament surgery. Physical Therapy, 71(6), 455–461. https://doi.org/10.1093/ptj/71.6.455

Fatahi, F., Ghasemi, G., Karimi, M., & Beyranvand, R. (2019). The effect of eight weeks of core stability training on lower extremity joint moments during single-leg drop landing. Baltic Journal of Health and Physical Activity, 11(1), 34–44. https://doi.org/10.29359/BJHPA.11.1.04

Fransen, M., McConnell, S., Harmer, A. R., Van der Esch, M., Simic, M., & Bennell, K. L. (2015). Exercise for osteoarthritis of the knee. Cochrane Database of Systematic Reviews, 2015(1). https://doi.org/10.1002/14651858.CD004376.pub3

Geng, R., Li, J., Yu, C., Zhang, C., Chen, F., Chen, J., Ni, H., Wang, J., Kang, K., Wei, Z., Xu, Y., & Jin, T. (2023). Knee osteoarthritis: Current status and research progress in treatment (review). Experimental and Therapeutic Medicine, 26(4). https://doi.org/10.3892/etm.2023.12180

Glass, N. A., Torner, J. C., Frey Law, L. A., Wang, K., Yang, T., Nevitt, M. C., Felson, D. T., Lewis, C. E., & Se-gal, N. A. (2013). The relationship between quadriceps muscle weakness and worsening of knee pain in the MOST cohort: A 5-year longitudinal study. Osteoarthritis and Cartilage, 21(9), 1154–1159. https://doi.org/10.1016/j.joca.2013.05.016

Hernandez, D., Dimaro, M., Navarro, E., Dorado, J., Accoce, M., Salzberg, S., & Policastro, P. O. (2019). Efficacy of core exercises in patients with osteoarthritis of the knee: A randomized controlled clinical trial. Journal of Bodywork and Movement Therapies, 23(4), 881–887. https://doi.org/10.1016/j.jbmt.2019.06.002

Hunter, D. J., & Bierma-Zeinstra, S. (2019). Osteoarthritis. The Lancet, 393(10182), 1745–1759. https://doi.org/10.1016/S0140-6736(19)30417-9

Karaborklu Argut, S., Celik, D., & Yasacı, Z. (2022). Effectiveness of therapeutic electromyographic biofeedback after orthopedic knee surgeries: A systematic review. Disability and Rehabilitati-on, 44(14), 3364–3372. https://doi.org/10.1080/09638288.2020.1867904

Kibler, W. B., Press, J., & Sciascia, A. (2006). The role of core stability in athletic function. Sports Medici-ne, 36(3), 189–198.

Kolasinski, S. L., Neogi, T., Hochberg, M. C., Oatis, C., Guyatt, G., Block, J., Callahan, L., Copenhaver, C., Dodge, C., Felson, D., Gellar, K., Harvey, W. F., Hawker, G., Herzig, E., Kwoh, C. K., Nelson, A. E., Samuels, J., Scanzello, C., White, D., … Reston, J. (2020). 2019 American College of Rheumatolo-gy/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis Care and Research, 72(2), 149–162. https://doi.org/10.1002/acr.24131

Lawford, B. J., Hall, M., Hinman, R. S., Van der Esch, M., Harmer, A. R., Spiers, L., Kemp, A., Dell’Isola, A., & Bennell, K. L. (2024). Exercise for osteoarthritis of the knee. Cochrane Database of Systematic Reviews, 2024(12). https://doi.org/10.1002/14651858.CD004376.pub4

Lee, K. (2021). The relationship of trunk muscle activation and core stability: A biomechanical analysis of Pilates-based stabilization exercise. International Journal of Environmental Research and Public Health, 18(23). https://doi.org/10.3390/ijerph182312804

Lepley, A. S., Gribble, P. A., & Pietrosimone, B. G. (2012). Effects of electromyographic biofeedback on quadriceps strength: A systematic review. Journal of Strength and Conditioning Research, 26(3), 873–882. https://doi.org/10.1519/JSC.0b013e318225ff75

Loeser, R. F., Goldring, S. R., Scanzello, C. R., & Goldring, M. B. (2012). Osteoarthritis: A disease of the joint as an organ. Arthritis and Rheumatism, 64(6), 1697–1707. https://doi.org/10.1002/art.34453

Mora, J. C., Przkora, R., & Cruz-Almeida, Y. (2018). Knee osteoarthritis: Pathophysiology and current treatment modalities. Journal of Pain Research, 11, 2189–2196. https://doi.org/10.2147/JPR.S154002

Myer, G. D., Chu, D. A., Brent, J. L., & Hewett, T. E. (2008). Trunk and hip control neuromuscular training for the prevention of knee joint injury. Clinics in Sports Medicine, 27(3), 425–448. https://doi.org/10.1016/j.csm.2008.02.006

Øiestad, B. E., Juhl, C. B., Eitzen, I., & Thorlund, J. B. (2015). Knee extensor muscle weakness is a risk factor for development of knee osteoarthritis: A systematic review and meta-analysis. Os-teoarthritis and Cartilage, 23(2), 171–177. https://doi.org/10.1016/j.joca.2014.10.008

Preece, S. J., Jones, R. K., Brown, C. A., Cacciatore, T. W., & Jones, A. K. P. (2016). Reductions in co-contraction following neuromuscular re-education in people with knee osteoarthritis. BMC Musculoskeletal Disorders, 17(1). https://doi.org/10.1186/s12891-016-1209-2

Raeissadat, S. A., Rayegani, S. M., Sedighipour, L., Bossaghzade, Z., Abdollahzadeh, M. H., Nikray, R., & Mollayi, F. (2018). The efficacy of electromyographic biofeedback on pain, function, and ma-ximal thickness of vastus medialis oblique muscle in patients with knee osteoarthritis: A ran-domized clinical trial. Journal of Pain Research, 11, 2781–2789. https://doi.org/10.2147/JPR.S169613

Ramadan Hafez, A., Al-Johani, A. H., Rahim Zakaria, A., Al-Ahaideb, A., & Kachanathu, J. (2013). Treat-ment of knee osteoarthritis in relation to hamstring and quadriceps strength. Journal of Physical Therapy Science, 25(11), 1401–1405.

Sahabuddin, F. N. A., Jamaludin, N. I., Amir, N. H., & Shaharudin, S. (2021). The effects of hip- and ankle-focused exercise intervention on dynamic knee valgus: A systematic review. PeerJ, 9. https://doi.org/10.7717/peerj.11731

Saki, F., Shafiee, H., Tahayori, B., & Ramezani, F. (2023). The effects of core stabilization exercises on neuromuscular function of athletes with ACL reconstruction. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-29126-6

Sasaki, S., Tsuda, E., Yamamoto, Y., Maeda, S., Kimura, Y., Fujita, Y., & Ishibashi, Y. (2019). Core-muscle training and neuromuscular control of the lower limb and trunk. Journal of Athletic Training, 54(9), 959–969. https://doi.org/10.4085/1062-6050-113-17

Setiawan, A., Aziz, Z., Supriyanto, S., Hidayatullah, N., Adyan, Z. A., Triasih, T., & Lelono, M. (2026). Inte-grated efriction method and injury level evaluation strategy for effective ACL knee injury reco-very. Retos, 78, 439–450. https://doi.org/10.47197/RETOS.V78.118675

Sharma, L., Song, J., Dunlop, D., Felson, D., Lewis, C. E., Segal, N., Torner, J., Cooke, T. D. V., Hietpas, J., Lynch, J., & Nevitt, M. (2010). Varus and valgus alignment and incident and progressive knee os-teoarthritis. Annals of the Rheumatic Diseases, 69(11), 1940–1945. https://doi.org/10.1136/ard.2010.129742

Sharma, L., Song, J., Felson, D. T., Cahue, S., Shamiyeh, E., & Dunlop, D. D. (2001). The role of knee align-ment in disease progression and functional decline in knee osteoarthritis. JAMA, 286(2), 188–195. https://doi.org/10.1001/jama.286.2.188

Steinmetz, J. D., Culbreth, G. T., Haile, L. M., Rafferty, Q., Lo, J., Fukutaki, K. G., Cruz, J. A., Smith, A. E., Vo-llset, S. E., Brooks, P. M., Cross, M., Woolf, A. D., Hagins, H., Abbasi-Kangevari, M., Abedi, A., Ackerman, I. N., Amu, H., Antony, B., Arabloo, J., … Kopec, J. A. (2023). Global, regional, and na-tional burden of osteoarthritis, 1990–2020 and projections to 2050: A systematic analysis for the Global Burden of Disease Study 2021. The Lancet Rheumatology, 5(9), e508–e522. https://doi.org/10.1016/S2665-9913(23)00163-7

Thomas, D. T., Eapen, C., Hegde, A. S., Mane, P. P., & Mehta, S. P. (2024). Impact of core muscle strengthening on knee pain, patient outcomes, physical function, and cartilage thickness in knee osteoarthritis: Protocol for a randomized controlled trial. MethodsX, 13. https://doi.org/10.1016/j.mex.2024.103008

Trisnowiyanto, B., Andriani, I., & Hendrik, H. (2026). Effectiveness of aquatic therapy on physical fun-ctional impairment in knee osteoarthritis: a meta-analysis study. Retos, 77, 315–323. https://doi.org/10.47197/retos.v77.117461

Van Rossom, S., Wesseling, M., Smith, C. R., Thelen, D. G., Vanwanseele, B., Dieter, V. A., & Jonkers, I. (2019). The influence of knee joint geometry and alignment on tibiofemoral load distribution: A computational study. The Knee, 26(4), 813–823. https://doi.org/10.1016/j.knee.2019.06.002

Viderman, D., Kalikanov, S., Myrkhiyeva, Z., Alisherov, S., Dossov, M., Seitenov, S., & Abdildin, Y. (2025). Impact of exercise therapy on outcomes in patients with low back pain: An umbrella review of systematic reviews. Journal of Clinical Medicine, 14(17). https://doi.org/10.3390/jcm14175942

Vos, T., Lim, S. S., Abbafati, C., Abbas, K. M., Abbasi, M., Abbasifard, M., Abbasi-Kangevari, M., Abbastabar, H., Abd-Allah, F., Abdelalim, A., Abdollahi, M., Abdollahpour, I., Abolhassani, H., Aboyans, V., Abrams, E. M., Abreu, L. G., Abrigo, M. R. M., Abu-Raddad, L. J., Abushouk, A. I., … Murray, C. J. L. (2020). Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019. The Lancet, 396(10258), 1204–1222. https://doi.org/10.1016/S0140-6736(20)30925-9

Yang, L., Sinsurin, K., Shen, F., Zhao, B., & Gao, T. (2024). Biomechanical changes in the lower extremity in individuals with knee osteoarthritis in the past decade: A scoping review. Heliyon, 10(11). https://doi.org/10.1016/j.heliyon.2024.e32642

Zeng, C. Y., Zhang, Z. R., Tang, Z. M., & Hua, F. Z. (2021). Benefits and mechanisms of exercise training for knee osteoarthritis. Frontiers in Physiology, 12. https://doi.org/10.3389/fphys.2021.794062

Downloads

Published

01-06-2026

Issue

Section

Original Research Article

How to Cite

Artz, A. M., Sahlan, A., Mubarak, H., Zainuddin, A. A., Waluyo, Y., & Sam, N. (2026). Core stabilization with biofeedback-guided quadriceps–hamstring strengthening in knee osteoarthritis: a randomized trial. Retos, 80, 835-846. https://doi.org/10.47197/retos.v80.119290