Effects of aerobic, strength, and combined exercise on cognitive functions in older adults: a systematic review
DOI:
https://doi.org/10.47197/retos.v60.107701Keywords:
prevention, aging, cognition, cognitive impairment, rehabilitationAbstract
Introduction: Aging is associated with a decline in cognitive functions, increasing the risk of neurocognitive impairment and limitation of activities of daily living and participation. Previous literature has pointed to physical exercise as an effective intervention; however, its characteristics still need to be specified. Objective: The aim was to synthesize the appropriate intensity, duration, frequency, and type of exercise for different types of cognitive variables. Method: A systematic review was carried out according to PRISMA, using three databases: PubMed, Scopus, and Web of Science. Experimental longitudinal studies were included, whether randomised or not, which performed physical exercise and with a control group in people over 60 years of age. Methodological quality was assessed using the PEDro scale. Results: The results yielded 11 studies finding significant improvements in all of them after performing the intervention (7 of aerobic exercise, 3 of resistance exercise and 2 of combined exercise) finding improvements in attention, memory, processing speed, executive function, inhibition, concentration, perceptual reasoning, orientation, visuospatial perception, and visuomotor organisation. Conclusions: Physical exercise appears to be a beneficial intervention for cognition in older people, with aerobic exercise being the most studied, although further research is needed. The results could benefit decision-making in rehabilitation to work on cognition in cognitively healthy older people.
Keywords: prevention; aging; cognition; cognitive impairment; rehabilitation.
References
Ahlskog, J. E., Geda, Y. E., Graff-Radford, N. R. & Petersen, R. C. (2011). Physical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging. Mayo Clinic Proceedings, 86(9), 876-884. https://doi.org/10.4065/mcp.2011.0252
*Albinet, C. T., Boucard, G., Bouquet, C. A. & Audiffren, M. (2010). Increased heart rate variability and executive perfor-mance after aerobic training in the elderly. European journal of applied physiology, 109(4), 617–624. https://doi.org/10.1007/s00421-010-1393-y
*Albinet, C. T., Abou-Dest, A., André, N. & Audiffren, M. (2016). Executive functions improvement following a 5-month aquaerobics program in older adults: Role of cardiac vagal control in inhibition performance. Biological psychology, 115, 69–77. https://doi.org/10.1016/j.biopsycho.2016.01.010
*Alghadir, A. H., Gabr, S. A. & Al-Eisa, E. S. (2016). Effects of Moderate Aerobic Exercise on Cognitive Abilities and Re-dox State Biomarkers in Older Adults. Oxidative medicine and cellular longevity, 2016, 2545168. https://doi.org/10.1155/2016/2545168
Alty, J., Farrow, M. & Lawler, K. (2020). Exercise and dementia prevention. Practical Neurology, 20(3), 234–240. https://doi.org/10.1136/practneurol-2019-002335
Alvarado García, A. M. & Salazar Maya, Á. M. (2014). Análisis del concepto de envejecimiento. Gerokomos, 25(2), 57-62.
Amagase, Y., Kambayashi, R., Sugiyama, A. & Takei, Y. (2023). Peripheral Regulation of Central Brain-Derived Neu-rotrophic Factor Expression through the Vagus Nerve. International Journal of Molecular Sciences, 24(4), 3543. https://doi.org/10.3390/ijms24043543
*Antunes, H. K., De Mello, M. T., de Aquino Lemos, V., Santos-Galduróz, R. F., Camargo Galdieri, L., Amodeo Bueno, O. F., Tufik, S. & D'Almeida, V. (2015). Aerobic physical exercise improved the cognitive function of elderly males but did not modify their blood homocysteine levels. Dementia and geriatric cognitive disorders extra, 5(1), 13–24. https://doi.org/10.1159/000369160
Arazi, H., Babaei, P., Moghimi, M. & Asadi, A. (2021). Acute effects of strength and endurance exercise on serum BDNF and IGF-1 levels in older men. BMC Geriatrics, 21(1). https://doi.org/10.1186/s12877-020-01937-6
Barnes, J. N. (2015). Exercise, cognitive function, and aging. Advances in physiology education, 39(2), 55–62. https://doi.org/10.1152/advan.00101.2014
Bausela, E. (2014). Funciones ejecutivas: nociones del desarrollo desde una perspectiva neuropsicológica. Acción Psicológica, 11(1), 21-34. https://dx.doi.org/10.5944/ap.1.1.13789
Bray, N. W., Pieruccini-Faria, F., Bartha, R., Doherty, T. J., Nagamatsu, L. S. & Montero-Odasso, M. (2021). The effect of physical exercise on functional brain network connectivity in older adults with and without cognitive impairment. A sys-tematic review. Mechanisms of Ageing and Development, 196, 111493. https://doi.org/10.1016/j.mad.2021.111493
*Brown, B. M., Frost, N., Rainey-Smith, S. R., Doecke, J., Markovic, S., Gordon, N., Weinborn, M., Sohrabi, H. R., Laws, S. M., Martins, R. N., Erickson, K. I. & Peiffer, J. J. (2021). High-intensity exercise and cognitive function in cognitively normal older adults: a pilot randomized clinical trial. Alzheimer's research & therapy, 13(1), 33. https://doi.org/10.1186/s13195-021-00774-y
Burke, S. N. & Barnes, C. A. (2006). Neural plasticity in the aging brain. Nature Reviews Neuroscience, 7(1), 30-40. https://doi.org/10.1038/nrn1809
Casas Herrero, Á., Cadore, E. L., Martínez Velilla, N., & Izquierdo Redin, M. (2015). El ejercicio físico en el anciano frágil: una actualización [Physical exercise in the frail elderly: an update]. Revista Española de Geriatría y Gerontología, 50(2), 74–81. https://doi.org/10.1016/j.regg.2014.07.003
Caspersen, C. J., Powell, K. E. & Christenson, G. M. (1985). Physical activity, exercise, and physical fitness: Definitions and distinctions for health-related research. Public Health Reports, 100(2), 126-131.
Chen, F. T., Etnier, J. L., Chan, K. H., Chiu, P. K., Hung, T. M. & Chang, Y. K. (2020). Effects of Exercise Training Inter-ventions on Executive Function in Older Adults: A Systematic Review and Meta-Analysis. Sports medicine (Auckland, N.Z.), 50(8), 1451–1467. https://doi.org/10.1007/s40279-020-01292-x
Cheng, S. T. (2016). Cognitive Reserve and the Prevention of Dementia: The Role of Physical and Cognitive Activities. Current psychiatry reports, 18(9), 85. https://doi.org/10.1007/s11920-016-0721-2
*Coelho-Junior, H., Marzetti, E., Calvani, R., Picca, A., Arai, H. & Uchida, M. (2020). Resistance training improves cogni-tive function in older adults with different cognitive status: A systematic review and Meta-analysis. Aging & Mental Health, 26(2), 213-224. https://doi.org/10.1080/13607863.2020.1857691
Contreras-Osorio, F., Ramirez-Campillo, R., Cerda-Vega, E., Campos-Jara, R., Martínez-Salazar, C., Araneda, R., Ebner-Karestinos, D., Arellano-Roco, C., & Campos-Jara, C. (2022). Effects of Sport-Based Exercise Interventions on Execu-tive Function in Older Adults: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health, 19(19), 12573. https://doi.org/10.3390/ijerph191912573
Cortez, A. C. leal, Vale, R. G. de S., Di Masi, F. D. M., Reis, N. C. V., Lucena, B. M., & Dantas, E. H. M. (2023). Eviden-cia científica sobre los efectos del entrenamiento resistente, aeróbico y de flexibilidad y sus adapta-ciones crónicas en la salud de los mayores (Scientific evidence about the effects of resisted, aerobic and flexibility training and their chronic adapta-tions in the health of the elderly). Retos, 48, 978–987. https://doi.org/10.47197/retos.v48.78231
Domingos, C., Pêgo, J. M., & Santos, N. C. (2021). Effects of physical activity on brain function and structure in older adults: A systematic review. Behavioural Brain Research, 402, 113061. https://doi.org/10.1016/j.bbr.2020.113061
Domínguez, R., Garnacho-Castaño, M. V. & Maté-Muñoz, J. L. (2016). Efectos del entrenamiento contra resistencias o resistance training en diversas patologías. Nutrición Hospitalaria, 33(3). https://dx.doi.org/10.20960/nh.284
Elkins, M. R., Moseley, A. M., Sherrington, C., Herbert, R. D. & Maher, C. G. (2013). Growth in the Physiotherapy Evi-dence Database (PEDro) and use of the PEDro scale. British Journal of Sports Medicine, 47(4), 188-189. https://doi.org/10.1136/bjsports-2012-091804
Fleg, J. L. (2012). Aerobic exercise in the elderly: A key to successful aging. Discovery Medicine, 13(70), 223-228.
Flores Tena, M. J., Deocano-Ruiz, Y., LLamas-Salguero, F., & Jiménez Morales, J. (2024). Envejecimiento active con las actividades de ocio y tiempo libre para una mayor calidad de vida (Active aging with leisure and free time activities for a better quality of life). Retos, 51, 1496–1501. https://doi.org/10.47197/retos.v51.99972
Font-Jutglà, C., M ur Gimeno, E., Bort Roig, J., Gomes da Silva, M. & Milà Villarroel, R. (2020). Efectos de la actividad física de intensidad suave sobre las condiciones físicas de los adultos mayores: Revisión sistemática. Revista Española de Ge-riatría y Gerontología, 55(2), 98-106. https://doi.org/10.1016/j.regg.2019.10.007
Friedman, N. P. & Miyake, A. (2017). Unity and diversity of Executive functions: Individual differences as a window on Cognitive structure. Cortex, 86, 186-204. https://doi.org/10.1016/j.cortex.2016.04.023
*Furlano, J. A., Horst, B. R., Petrella, R. J., Shoemaker, J. K. & Nagamatsu, L. S. (2023). Changes in cognition and brain function after 26 weeks of Progressive Resistance Training in older adults at risk for diabetes: a pilot randomized con-trolled trial. Canadian Journal of Diabetes, 47(3), 250-256. https://doi.org/10.1016/j.jcjd.2023.01.004
Garber, C. E., Blissmer, B., Deschenes, M. R., Franklin, B. A., Lamonte, M. J., Lee, I. M., Nieman, D. C., Swain, D. P., & American College of Sports Medicine (2011). American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Medicine and Science in Sports and Exercise, 43(7), 1334–1359. https://doi.org/10.1249/MSS.0b013e318213fefb
Glisky, E. L. (2007). Changes in Cognitive Function in Human Aging. En D. R. Riddle (Ed.), Brain Aging: Models, Methods, and Mechanisms. CRC Press/Taylor & Francis.
Gómez-Conesa, A., Serrano, C. S., Matamoros, D. C. & López-López, J. A. (2015). The Spanish translation and adaptation of the Pedro scale. Physiotherapy, 101, e463-e464. https://doi.org/10.1016/j.physio.2015.03.3250
Harvey, P. D. (2019). Domains of cognition and their assessment. Dialogues in Clinical Neuroscience, 21(3), 227-237. https://doi.org/10.31887%2FDCNS.2019.21.3%2Fpharvey
Herold, F., Törpel, A., Schega, L. & Müller, N. G. (2019). Functional and/or structural brain changes in response to re-sistance exercises and resistance training lead to cognitive improvements - a systematic review. European review of aging and physical activity: official journal of the European Group for Research into Elderly and Physical Activity, 16, 10. https://doi.org/10.1186/s11556-019-0217-2
Heyn, P. C., Johnson, K. E. & Kramer, A. F. (2008). Endurance and strength training outcomes on cognitively impaired and cognitively intact older adults: a meta-analysis. The Journal of Nutrition, Health & Aging, 12(6), 401–409. https://doi.org/10.1007/BF02982674
Hortobágyi, T., Vetrovsky, T., Balbim, G. M., Sorte Silva, N. C. B., Manca, A., Deriu, F., Kolmos, M., Kruuse, C., Liu-Ambrose, T., Radák, Z., Váczi, M., Johansson, H., Dos Santos, P. C. R., Franzén, E. & Granacher, U. (2022). The im-pact of aerobic and resistance training intensity on markers of neuroplasticity in health and disease. Ageing research reviews, 80, 101698. https://doi.org/10.1016/j.arr.2022.101698
*Jonasson, L. S., Nyberg, L., Kramer, A. F., Lundquist, A., Riklund, K. & Boraxbekk, C. J. (2017). Aerobic Exercise Inter-vention, Cognitive Performance, and Brain Structure: Results from the Physical Influences on Brain in Aging (PHIBRA) Study. Frontiers in aging neuroscience, 8, 336. https://doi.org/10.3389/fnagi.2016.00336
Kassa, M. D. & Grace, J. M. (2020). Frequency, intensity, time, and type principle of physical activity as a medical disability prevention program in ethiopia: A mixed-method study. Indian Journal of Public Health, 64(2), 141-147. https://doi.org/10.4103/ijph.IJPH_418_18
Kirk-Sanchez, N. J & McGough, E. L. (2013). Physical exercise and cognitive performance in the elderly: Current perspec-tives. Clinical Interventions in Aging, 9, 51–62. https://doi.org/10.2147/cia.s39506
Larson, E. B., Wang, L., Bowen, J. D., McCormick, W. C., Teri, L., Crane, P. & Kukull, W. (2006). Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Annals of internal medicine, 144(2), 73–81. https://doi.org/10.7326/0003-4819-144-2-200601170-00004
Liu-Ambrose, T., Nagamatsu, L. S., Graf, P., Beattie, B. L., Ashe, M. C., & Handy, T. C. (2010). Resistance training and executive functions: a 12-month randomized controlled trial. Archives of Internal Medicine, 170(2), 170–178. https://doi.org/10.1001/archinternmed.2009.494
Lojo-Seoane, C., Facal, D., Guàrdia-Olmos, J., Pereiro, A. X. & Juncos-Rabadán, O. (2018). Effects of Cognitive Reserve on Cognitive Performance in a Follow-Up Study in Older Adults with Subjective Cognitive Complaints. The Role of Working Memory. Frontiers in Aging Neuroscience, 10, 189. https://doi.org/10.3389/fnagi.2018.00189
Lu, Y., Bu, F. Q., Wang, F., Liu, L., Zhang, S., Wang, G. & Hu, X. Y. (2023). Recent advances on the molecular mecha-nisms of exercise-induced improvements of cognitive dysfunction. Translational neurodegeneration, 12(1), 9. https://doi.org/10.1186/s40035-023-00341-5
Ministerio del deporte (MINDEP) (2020). Actividad física previene la pérdida de masa muscular en adultos mayores. https://www.mindep.cl/actividades/noticias/1511
Miyake, A., Friedman, N. P., Emerson, M. J., Witzki, A. H., Howerter, A. & Wager, T. D. (2000). The unity and diversity of executive functions and their contributions to complex «Frontal Lobe» tasks: A latent variable analysis. Cognitive Psy-chology, 41(1), 49-100. https://doi.org/10.1006/cogp.1999.0734
Morris, J. K., Vidoni, E. D., Johnson, D. K., Van Sciver, A., Mahnken, J. D., Honea, R. A., Wilkins, H. M., Brooks, W. M., Billinger, S. A., Swerdlow, R. H. & Burns, J. M. (2017). Aerobic exercise for Alzheimer’s disease: A randomized controlled pilot trial. PLoS ONE, 12(2), e0170547. https://doi.org/10.1371/journal.pone.0170547
Murman, D. L. (2015). The Impact of Age on Cognition. Seminars in Hearing, 36(3), 111-121. https://doi.org/10.1055/s-0035-1555115
*Nagamatsu, L. S., Chan, A., Davis, J. C., Beattie, B. L., Graf, P., Voss, M. W., Sharma, D., & Liu-Ambrose, T. (2013). Physical activity improves verbal and spatial memory in older adults with probable mild cognitive impairment: a 6-month randomized controlled trial. Journal of aging research, 2013, 861893. https://doi.org/10.1155/2013/861893
* Napoli, N., Shah, K., Waters, D. L., Sinacore, D. R., Qualls, C. & Villareal, D. T. (2014). Effect of weight loss, exercise, or both on cognition and quality of life in obese older adults. The American Journal of Clinical Nutrition, 100(1), 189–198. https://doi.org/10.3945/ajcn.113.082883
Northey, J. M., Cherbuin, N., Pumpa, K. L., Smee, D. J. & Rattray, B. (2018). Exercise interventions for cognitive function in adults older than 50: a systematic review with meta-analysis. British Journal of Sports Medicine, 52(3), 154–160. https://doi.org/10.1136/bjsports-2016-096587
Oliveira, A., Fidalgo, A., Farinatti, P. & Monteiro, W. (2024). Effects of high-intensity interval and continuous moderate aerobic training on fitness and health markers of older adults: A systematic review and meta-analysis. Archives of gerontolo-gy and geriatrics, 124, 105451. https://doi.org/10.1016/j.archger.2024.105451
Paci, M., Bianchini, C. & Baccini, M. (2022). Reliability of the PEDro scale: Comparison between trials published in preda-tory and non-predatory journals. Archives of Physiotherapy, 12(1), 10. https://doi.org/10.1186/s40945-022-00133-6
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., Moher, D., . . . Alonso-Fernández, S. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372, n71. https://doi.org/10.1016/j.recesp.2021.06.016
Radak, Z., Hart, N., Sarga, L., Koltai, E., Atalay, M., Ohno, H. & Boldogh, I. (2010). Exercise plays a preventive role against Alzheimer's disease. Journal of Alzheimer's disease: JAD, 20(3), 777–783. https://doi.org/10.3233/JAD-2010-091531
Ramírez-Campillo, R., Castillo, D., Raya-González, J., Moran, J., de Villarreal, E. S. & Lloyd, R. S. (2020). Effects of Plyometric Jump Training on Jump and Sprint Performance in Young Male Soccer Players: A Systematic Review and Me-ta-analysis. Sports Medicine, 50(12), 2125-2143. https://doi.org/10.1007/s40279-020-01337-1
Rojas, F. H., Canache, L. R. & León, J. R. (2022). Envejecimiento en Chile: Evolución, características de las personas mayo-res y desafíos demográficos para la población. Chile: Instituto Nacional de Estadísticas.
Salech, M., Jara, L. R. & Michea, A. L. (2012). Cambios fisiológicos asociados al envejecimiento. Revista Médica Clínica Las Condes, 23(1), 19-29.
Sanders, L. M. J., Hortobágyi, T., la Bastide-van Gemert, S., van der Zee, E. A. & van Heuvelen, M. J. G. (2019). Dose-response relationship between exercise and cognitive function in older adults with and without cognitive impairment: A systematic review and meta-analysis. PloS one, 14(1), e0210036. https://doi.org/10.1371/journal.pone.0210036
Seok, J. W., Kim, G. & Kim, J. U. (2024). Comparative efficacy of seven nonpharmacological interventions on global cogni-tion in older adults with and without mild cognitive impairment: a network meta-analysis of randomized controlled trials. Scientific reports, 14(1), 8402. https://doi.org/10.1038/s41598-024-58232-2
Shankar, S. K. (2010). Biology of aging brain. Indian Journal of Pathology & Microbiology, 53(4), 595-604. https://doi.org/10.4103/0377-4929.71995
Suryadi, D., Komaini, A., Suganda, M. A., Rubiyatno, R., Faridah, E., Fauzan, L. A., Fauziah, E., Putra, M. E. & Ayubi, N. (2024). Salud deportiva en la vejez: prevalencia y factores de riesgo - Revisión sistemática (Sports Health in Older Age: Prevalence and Risk Factors - Systematic Review). Retos, 53, 390–399. https://doi.org/10.47197/retos.v53.102654
Tarassova, O., Ekblom, M., Moberg, M., Lövdén, M. & Nilsson, J. (2020). Peripheral BDNF response to physical and cogni-tive exercise and its association with cardiorespiratory fitness in healthy older adults. Frontiers in Physiology, 11. https://doi.org/10.3389/fphys.2020.01080
Thompson, P. D., Arena, R., Riebe, D., Pescatello, L. S. & American College of Sports Medicine (2013). ACSM's new preparticipation health screening recommendations from ACSM's guidelines for exercise testing and prescription, ninth edition. Current sports medicine reports, 12(4), 215–217. https://doi.org/10.1249/JSR.0b013e31829a68cf
Turner, D. T., Hu, M. X., Generaal, E., Bos, D., Ikram, M. K., Heshmatollah, A., Fani, L., Ikram, M. A., Penninx, B. W. J. H. & Cuijpers, P. (2021). Physical Exercise Interventions Targeting Cognitive Functioning and the Cognitive Domains in Nondementia Samples: A Systematic Review of Meta-Analyses. Journal of Geriatric Psychiatry and Neurology, 34(2), 91–101. https://doi.org/10.1177/0891988720915523
United Nations, Department of Economic and Social Affairs, Population Division. (2022). World Population Prospects 2022: Summary of Results. https://www.un.org/development/desa/pd/sites/www.un.org.development.desa.pd/files/wpp2022_summary_of_results.pdf
Vaynman, S., Ying, Z. & Gomez-Pinilla, F. (2004). Hippocampal BDNF mediates the efficacy of exercise on synaptic plastici-ty and cognition. European Journal of Neuroscience, 20(10), 2580-2590. https://doi.org/10.1111/j.1460-9568.2004.03720.x
* Vedovelli, K., Giacobbo, B. L., Corrêa, M. S., Wieck, A., Argimon, I. I. L. & Bromberg, E. (2017). Multimodal physical activity increases brain-derived neurotrophic factor levels and improves cognition in institutionalized older women. Gero-Science, 39(4), 407–417. https://doi.org/10.1007/s11357-017-9987-5
Wilson, M. (2002). Six views of embodied cognition. Psychonomic Bulletin & Review, 9(4), 625-636. https://doi.org/10.3758/BF03196322
Wong, M. Y. C., Ou, K., Chung, P. K., Chui, K. Y. K. & Zhang, C. (2023). The relationship between physical activity, physical health, and mental health among older Chinese adults: A scoping review. Frontiers in Public Health, 10, 914548. https://doi.org/10.3389%2Ffpubh.2022.914548
World Health Organization (WHO) (2022a). Ageing and health. https://www.who.int/es/news-room/fact-sheets/detail/ageing-and-health
World Health Organization (WHO) (2022b). Actividad Física. https://www.who.int/es/news-room/fact-sheets/detail/physical-activity
Xu, L., Gu, H., Cai, X., Zhang, Y., Hou, X., Yu, J. & Sun, T. (2023). The Effects of Exercise for Cognitive Function in Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. International Journal of Environ-mental Research and Public Health, 20(2), 1088. https://doi.org/10.3390/ijerph20021088
Yang, J., Dong, Y., Yan, S., Yi, L. & Qiu, J. (2023). Which Specific Exercise Models Are Most Effective on Global Cognition in Patients with Cognitive Impairment? A Network Meta-Analysis. International journal of environmental research and public health, 20(4), 2790. https://doi.org/10.3390/ijerph20042790
Zavala M. G., Vidal D. G., Castro M. S., Quiroga, P. & Klassen G. P., (2006). Funcionamiento Social del Adulto Mayor. Ciencia y enfermería, 12(2). http://dx.doi.org/10.4067/S0717-95532006000200007
Zhang, W., Zhou, C. & Chen, A. (2024). A systematic review and meta-analysis of the effects of physical exercise on white matter integrity and cognitive function in older adults. GeroScience, 46(2), 2641–2651. https://doi.org/10.1007/s11357-023-01033-8
Zhao, Y., Li, Y., Wang, L., Song, Z., Di, T., Dong, X., Song, X., Han, X., Zhao, Y., Wang, B., Cui, H., Chen, H. & Li, S. (2022). Physical Activity and Cognition in Sedentary Older Adults: A Systematic Review and Meta-Analysis. Journal of Alzheimer's disease: JAD, 87(3), 957–968. https://doi.org/10.3233/JAD-220073
Zheng, G., Ye, B., Zheng, Y., Xiong, Z., Xia, R., Qiu, P., Tao, J., & Chen, L. (2019). The effects of exercise on the struc-ture of cognitive related brain regions: A meta-analysis of functional neuroimaging data. The International Journal of Neuro-science, 129(4), 406-415. https://psycnet.apa.org/doi/10.1080/00207454.2018.1508135
Zhou, X. L., Wang, L. N., Wang, J., Zhou, L. & Shen, X. H. (2020). Effects of exercise interventions for specific cognitive domains in old adults with mild cognitive impairment: A meta-analysis and subgroup analysis of randomized controlled trials. Medicine, 99(31), e20105. https://doi.org/10.1097/MD.0000000000020105
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Retos

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and ensure the magazine the right to be the first publication of the work as licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of authorship of the work and the initial publication in this magazine.
- Authors can establish separate additional agreements for non-exclusive distribution of the version of the work published in the journal (eg, to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Is allowed and authors are encouraged to disseminate their work electronically (eg, in institutional repositories or on their own website) prior to and during the submission process, as it can lead to productive exchanges, as well as to a subpoena more Early and more of published work (See The Effect of Open Access) (in English).
This journal provides immediate open access to its content (BOAI, http://legacy.earlham.edu/~peters/fos/boaifaq.htm#openaccess) on the principle that making research freely available to the public supports a greater global exchange of knowledge. The authors may download the papers from the journal website, or will be provided with the PDF version of the article via e-mail.