Effects of therapeutic exercise on pelvic pain in women with endometriosis: systematic review and meta-analysis

Authors

  • Yoselyn Reyes Sánchez Universidad Santo tomas
  • Karen Saint Thomas Aquinas University
  • Javiera Anjel Sepúlveda Saint Thomas Aquinas University

DOI:

https://doi.org/10.47197/retos.v73.116828

Keywords:

Endometriosis, pelvic pain, therapeutic exercise, physiotherapy, quality of life

Abstract

Introduction: Endometriosis is a chronic gynecological condition characterized by pelvic pain, dysmenorrhea, and functional impairment. Although conventional treatments provide partial symptom relief, clinical limitations persist. Therapeutic exercise has emerged as an effective complementary intervention.

Objective: To systematically evaluate the effect of therapeutic exercise and supervised physical interventions on pelvic pain in women with endometriosis.

Methods: A systematic search was conducted in PubMed, Scopus, Web of Science, Cochrane Library, and Google Scholar (1995–May 2025), including controlled trials, pre-post studies, and observational designs with objective pain assessment. Meta-analysis was performed using a random-effects model (Hedges' g), heterogeneity analysis (I²), and publication bias assessment (Egger’s test).

Results: A total of 2,721 records were identified. After applying inclusion criteria, 7 studies were analyzed, of which 5 provided quantitative data (N = 226). The overall effect size was Hedges' g = -1.73 (95% CI: -2.42 to -1.04), indicating a significant reduction in pain. Heterogeneity was moderate to high (I² = 62.8%). Subgroup analysis showed greater benefits for supervised exercise (g = -2.90), manual therapy/hydrotherapy (g = -2.00), yoga (g = -1.56), and somatosensory psychotherapy (g = -1.17), while digital interventions showed smaller effects (g = -0.50). No publication bias was detected (Egger p = 0.73).

Conclusions: Supervised therapeutic exercise significantly reduces pelvic pain in women with endometriosis, with multicomponent face-to-face interventions showing the greatest clinical efficacy.

Author Biographies

  • Karen, Saint Thomas Aquinas University

    Kinesiology student

  • Javiera Anjel Sepúlveda, Saint Thomas Aquinas University

    Kinesiology student

References

Artacho-Cordón, F., Salinas-Asensio, M. D. M., Galiano-Castillo, N., Ocón-Hernández, O., Peinado, F. M., Mundo-López, A., Lozano-Lozano, M., Álvarez-Salvago, F., Arroyo-Morales, M., Fernández-Lao, C., & Cantarero-Villanueva, I. (2023). Effect of a supervised multimodal therapeutic exercise program on quality of life, pain, and lumbopelvic deficits in women with endometriosis unres-ponsive to conventional therapy: A randomized controlled trial. Archives of Physical Medicine and Rehabilitation, 104(11), 1785–1795. https://doi.org/10.1016/j.apmr.2023.06.020

Awad, E., Ahmed, H. A. H., Yousef, A., & Abbas, R. (2017). Efficacy of exercise on pelvic pain and posture associated with endometriosis: Within subject design. Journal of Physical Therapy Science, 29(12), 2112–2115. https://doi.org/10.1589/jpts.29.2112

Carpenter, S. E., Tjaden, B., Rock, J. A., & Kimball, A. (1995). The effect of regular exercise on women receiving danazol for treatment of endometriosis. International Journal of Gynaecology and Obstetrics, 49(3), 299–304. https://doi.org/10.1016/0020-7292(95)02359-k

Ensari, I., Kosunen, E., Clarke-Pearson, E., Patton, T., Sutton, K., Siedhoff, M., & Williams, N. (2022). Real-world physical activity and endometriosis symptoms: A mHealth-based daily assessment feasibility study. BMJ Open, 12(6), e059280. https://doi.org/10.1136/bmjopen-2021-059280

Farland, L. V., Prescott, J., Sasamoto, N., Tobias, D. K., Gaskins, A. J., Stuart, J. J., Carusi, D. A., Chavarro, J. E., Horne, A. W., Rich-Edwards, J. W., & Missmer, S. A. (2019). Endometriosis and risk of adverse pregnancy outcomes. Obstetrics and Gynecology, 134(3), 527–536. https://doi.org/10.1097/AOG.0000000000003410

Gentles, A., Goodwin, E., Bedaiwy, Y., Marshall, N., & Yong, P. J. (2024). Nociplastic pain in endometrio-sis: An exploratory review. Journal of Clinical Medicine, 13(24), 7521. https://doi.org/10.3390/jcm13247521

Gonçalves, A. V., Barros, N. F., & Bahamondes, L. (2017). The practice of Hatha Yoga for the treatment of pain associated with endometriosis. Journal of Alternative and Complementary Medicine, 23(1), 45–52. https://doi.org/10.1089/acm.2015.0343

Khalid, A., Naeem, A., Israr, F., & Akram, M. (2024). Effect of relaxation, lumbopelvic stabilization, and strengthening on pain, quality of life, and lumbopelvic impairments in women with endometriosis. Journal of Health and Rehabilitation Research, 4(2), 1803–1806. https://doi.org/10.61919/jhrr.v4i2.1192

Kuśnierz, A., Kusiak, K., Głąbień, M., Miłkowski, P., Aleksandrowicz, D., Wieczorek, O., Jakubczak, Z., Kondratowicz, A., Zimniak, M. W., & Śliwiak, P. (2024). The impact of physical activity and ex-ercise on endometriosis-related symptoms with particular emphasis on pain: Systematic re-view. Quality in Sport, 22, 54704. https://doi.org/10.12775/QS.2024.22.54704

Li, Y., Hung, S. W., Zhang, R., Man, G. C., Zhang, T., Chung, J. P., Fang, L., & Wang, C. C. (2022). Melatonin in endometriosis: Mechanistic understanding and clinical insight. Nutrients, 14(19), 4087. https://doi.org/10.3390/nu14194087

Lutfi, M., Dalleck, L. C., Drummond, C., Drummond, M., Paparella, L., Keith, C. E., Kirton, M., Falconer, L., Gebremichael, L., Phelan, C., Barry, C., Roscio, K., Lange, B., & Ramos, J. S. (2023). A single session of a digital health tool-delivered exercise intervention may provide immediate relief from pel-vic pain in women with endometriosis: A pilot randomized controlled study. International Journal of Environmental Research and Public Health, 20(3), 1665. https://doi.org/10.3390/ijerph20031665

McKnight, K., Omotosho, O., Jassim, S., & Cotter, A. (2024). Exercise and endometriosis—Is there a promising future? A narrative review. Irish Journal of Medical Science, 193(5), 2375–2387. https://doi.org/10.1007/s11845-024-03733-2

Meissner, K., Schweizer-Arau, A., Limmer, A., Preibisch, C., Popovici, R. M., Lange, I., de Oriol, B., & Beissner, F. (2016). Psychotherapy with somatosensory stimulation for endometriosis-associated pain: A randomized controlled trial. Obstetrics and Gynecology, 128(5), 1134–1142. https://doi.org/10.1097/AOG.0000000000001691

Rabieezadeh, R., Hosseinimehr, S. H., Akbari, M., & Hemmati, L. (2024). Effect of neuromuscular dynamic stabilization exercises on pain, functional disability and quality of life in chronic nonspecific low back pain: A randomized controlled trial. BMC Sports Science, Medicine and Rehabilitation, 16(1), 68. https://doi.org/10.1186/s13102-024-00948-9

Rodríguez-Ruiz, Á., Arcos-Azubel, C., Ruiz-Pérez, M., Peinado, F. M., Mundo-López, A., Lara-Ramos, A., Salinas-Asensio, M. D. M., & Artacho-Cordón, F. (2024). The benefits of an integral HAMMAM ex-perience combining hydrotherapy and Swedish massage on pain, subjective well-being and quality of life in women with endometriosis-related chronic pelvic pain: A randomized con-trolled trial. Medicina (Kaunas, Lithuania), 60(10), 1677. https://doi.org/10.3390/medicina60101677

Salinas-Asensio, M. D. M., Ocón-Hernández, O., Mundo-López, A., Fernández-Lao, C., Peinado, F. M., Padi-lla-Vinuesa, C., Álvarez-Salvago, F., Postigo-Martín, P., Lozano-Lozano, M., Lara-Ramos, A., Arro-yo-Morales, M., Cantarero-Villanueva, I., & Artacho-Cordón, F. (2022). ‘Physio-EndEA’ study: A randomized, parallel-group controlled trial to evaluate the effect of a supervised and adapted therapeutic exercise program to improve quality of life in symptomatic women diagnosed with endometriosis. International Journal of Environmental Research and Public Health, 19(3), 1738. https://doi.org/10.3390/ijerph19031738

Saragiotto, B. T., Maher, C. G., Yamato, T. P., Costa, L. O. P., Menezes Costa, L. C., Ostelo, R. W. J. G., Mace-do, L. G., & McAuley, J. H. (2016). Motor control exercise for chronic non-specific low-back pain. Cochrane Database of Systematic Reviews, 2016(1), CD012004. https://doi.org/10.1002/14651858.CD012004

Song, S. Y., Jung, Y. W., Shin, W., Park, M., Lee, G. W., Jeong, S., An, S., Kim, K., Ko, Y. B., Lee, K. H., Kang, B. H., Lee, M., & Yoo, H. J. (2023). Endometriosis-related chronic pelvic pain. Biomedicines, 11(10), 2868. https://doi.org/10.3390/biomedicines11102868

Tennfjord, M. K., Gabrielsen, R., Bø, K., Engh, M. E., & Molin, M. (2024). Can general exercise training and pelvic floor muscle training be used as an empowering tool among women with endometriosis? Experiences among women with endometriosis participating in the intervention group of a randomized controlled trial. BMC Women's Health, 24(1), 505. https://doi.org/10.1186/s12905-024-03356-w

Vannuccini, S., Lazzeri, L., Orlandini, C., Morgante, G., Bifulco, G., & Petraglia, F. (2022). Pharmacological treatments for endometriosis: Current and emerging therapies. Expert Opinion on Pharmacot-herapy, 23(2), 127–139. https://doi.org/10.1080/14656566.2021.2004552

Xie, M., Qing, X., Huang, H., Zhang, L., Tu, Q., Guo, H., & Zhang, J. (2025). The effectiveness and safety of physical activity and exercise on women with endometriosis: A systematic review and meta-analysis. PLOS ONE, 20(2), e0317820. https://doi.org/10.1371/journal.pone.0317820

Zondervan, K. T., Becker, C. M., & Missmer, S. A. (2020). Endometriosis. The New England Journal of Medicine, 382(13), 1244–1256. https://doi.org/10.1056/NEJMra1810764

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Published

21-10-2025

Issue

Section

Theoretical systematic reviews and/or meta-analysis

How to Cite

Reyes Sánchez, Y., Alarcón Obreque, K., & Anjel Sepúlveda, J. (2025). Effects of therapeutic exercise on pelvic pain in women with endometriosis: systematic review and meta-analysis. Retos, 73, 813-825. https://doi.org/10.47197/retos.v73.116828