Curcumin: The active compound in turmeric has the potential to reduce pain intensity and increase range of motion during exercise-induced muscle damage
DOI:
https://doi.org/10.47197/retos.v49.98671Keywords:
Curcumin, Pain Intensity, Range of Motion, Exercise-Induced Muscle Damage, InflammationAbstract
This study aims to analyze and prove the effect of curcumin on pain intensity and ROM during EIMD. This experimental study used a pre and post-control group design. Research subjects were selected using a purposive sampling technique and then the subjects were divided into 2 groups, namely the group given a placebo and the group was given curcumin at a dose of 400 mg. A total of 24 healthy men aged between 20-30 years participated in this study. On the first day, all subjects took data on the characteristics of research subjects, then warmed up. Then the subjects did the high-intensity physical exercise in the form of squad and leg press exercises with an intensity of 80-90% of maximum ability. The exercise was carried out in 4 sets for each form of exercise and rest between sets for about 1 minute. On the second day, after 24 hours the subject took pre-test data to measure pain intensity and ROM, then the intervention was given based on each group. On the third day, after 24 hours the subject took post-test data to measure pain intensity and ROM. Measurement of pain intensity using the Visual Analytical Scale (VAS) and measurement of ROM performed in the knee joint using a goniometer. After the data was obtained, the data were analyzed using the IBM SPSS version 26 application. The results of this study reported that the group given curcumin during EIMD was able to significantly reduce pain intensity (*p<0.05) compared to the group given a placebo. Furthermore, the group given curcumin during EIMD was able to increase ROM significantly (*p<0.05) compared to the placebo group. We believe that the main cause of muscle soreness is the uncontrolled increase in pro-inflammatory cytokines such as TNF-a and IL-6 during EIMD and then decreased ROM for several days after exercise. Since pain intensity and ROM are needed to support body functions, we highly recommend the use of curcumin, which has many positive benefits for sports enthusiasts to support physical performance.
Keywords: Curcumin, Pain Intensity, Range of Motion, Exercise-Induced Muscle Damage, Inflammation
References
Anugrah, S.M. et al. Effect of Royal Jelly on Performance and Inflammatory Response to Muscle Damage: A Systematic Review. Biointerface Research in Applied Chemistry (2023). 13(5), 6–13. https://doi.org/10.33263/BRIAC135.479.
Ayubi N, Yuniarti E, Kusnanik NW, et al. Acute effects of n-3 polyunsaturated fatty acids ( PUFAs ) reducing tumor necrosis factor-alpha ( TNF- a ) levels and not lowering malondialdehyde ( MDA ) levels after anaerobic exercise. Journal of Biological Regulators and Homeostatic Agents (2022). 36(1), 7-11. https://doi.org10.23812/21-468-A.
Ayubi N, Purwanto B Rejeki, PS Kusnanik NW, Herawati L, Komaini A, Mutohir, TC, Nurhasan N, Ardha MAA, & Firmansyah A. Effect of acute omega 3 supplementation reduces serum tumor necrosis factor-alpha (TNF-a) levels, pain intensity, and maintains muscle strength after high-intensity weight training. Retos (2022). 46(1),677-682. https://doi.org/10.47197/retos.v46.93720.
Ayubi, N. et al. Effects of Curcumin on Inflammatory Response During Exercise-Induced Muscle Damage ( Literature Review). Biointerface Research in Applied Chemistry (2023). 13(2), 1–19. https://doi.org/10.33263/BRIAC132.146.
Barchitta M, Maugeri A, Favara G, et al. Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin. Int J Mol Sci (2019). 20(5), 1-14. https://doi.org/10.3390/ijms20051119.
Boarescu I, Pop RM, Boarescu PM, et al. Anti-Inflammatory and Analgesic Effects of Curcumin Nanoparticles Associated with Diclofenac Sodium in Experimental Acute Inflammation. Int J Mol Sci (2022). 23(19), 1-16. https://doi.org10.3390/ijms231911737.
Chang WD, Lin HY, Chang NJ, Wu JH. Effects of 830 nm Light-Emitting Diode Therapy on Delayed-Onset Muscle Soreness. Evidence-based Complement Altern Med (2021). Special Issue 2021, 1-7. https://doi.org/10.1155/2021/6690572.
Chen G, Liu S, Pan R, et al. Curcumin Attenuates gp120-Induced Microglial Inflammation by Inhibiting Autophagy via the PI3K Pathway. Cell Mol Neurobiol (2018). 38(8), 1465-1477. https://doi.org/10.1007/s10571-018-0616-3.
Chowdhury I, Banerjee S, Driss A, et al. Curcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF‐$κ$B signaling pathway. J Cell Physiol (2019). 234, 6298-6312. https://doi.org/10.1002/jcp.27360.
Devi AI, et al. Response of TNF-α Levels and Blood Glucose Levels after Acute High-Intensity Intermittent Exercise in Overweight Women. Retos (2023). 48, 101–105. https://doi.org/10.47197/retos.v48.94305.
Fernández-Lázaro D, Mielgo-Ayuso J, Calvo JS, Martínez AC, García AC, Fernandez-Lazaro CI. Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: A systematic review. Nutrients (2020). 12(2), 1-2. https://doi.org/10.3390/nu12020501.
Godersky ME, Vercammen LK, Ventura AS, Walley AY, Saitz R. Identification of non-steroidal anti-inflammatory drug use disorder: A case report. Addict Behav (2017). 70, 61-64. https://doi.org/10.1016/j.addbeh.2017.02.008.
Hody S, Croisier JL, Bury T, Rogister B, Leprince P. Eccentric Muscle Contractions: Risks and Benefits. Front Physiol (2019). 10, 1-18. https://doi.org/10.3389/fphys.2019.00536.
Howatson G, Hoad M, Goodall S, Tallent J, Bell PG, French DN. Exercise-induced muscle damage is reduced in resistance-trained males by branched chain amino acids: a randomized, double-blind, placebo controlled study. J Int Soc Sports Nutr (2012). 9(1), 1-7. https://doi.org/10.1186/1550-2783-9-20.
Hung BL, Sun CY, Chang NJ, Chang WD. Effects of Different Kinesio-Taping Applications for Delayed Onset Muscle Soreness after High-Intensity Interval Training Exercise: A Randomized Controlled Trial. Evidence-based Complement Altern Med (2021). Special Issue 2021, 1-10. https://doi.org/10.1155/2021/6676967.
Jamurtas AZ. Exercise-Induced Muscle Damage and Oxidative Stress. Antioxidants (2018). 7(4), 1-3. https://doi.org/10.3390/antiox7040050.
Kafrawi, FR, et al. Massage Has the Potential to Accelerate Recovery and Decrease Muscle Soreness after Physical Exercise (Literature Review), International Journal of Human Movement and Sports Sciences (2023). 11(1), 170–175. https://doi.org/10.13189/saj.2023.110120.
Konrad A, Kasahara K, Yoshida R, et al. Relationship between Eccentric-Exercise-Induced Loss in Muscle Function to Muscle Soreness and Tissue Hardness. Healthc (Basel, Switzerland) (2022). 10(1), 96. https://doi.org/10.3390/healthcare10010096.
Lao CD, et al. Dose escalation of a curcuminoid formulation.’, BMC complementary and alternative medicine (2006). 6(1), 10. https://doi.org/10.1186/1472-6882-6-10.
Li QY, Xu HY, Yang HJ. [Effect of proinflammatory factors TNF-α,IL-1β, IL-6 on neuropathic pain]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China J Chinese Mater medica (2017). 42(19), 3709-3712. https://doi.org/10.19540/j.cnki.cjcmm.20170907.004.
Muljadi JA, Kaewphongsri P, Chaijenkij K, Kongtharvonskul J. Effect of caffeine on delayed-onset muscle soreness: a meta-analysis of RCT. Bull Natl Res Cent (2021). 46(197), 1-11. https://doi.org/10.1186/s42269-021-00660-5.
Nanavati K, Rutherfurd-Markwick K, Lee SJ, Bishop NC, Ali A. Effect of curcumin supplementation on exercise-induced muscle damage: a narrative review. Eur J Nutr (2022). 61(1), 3835-3855. https://doi.org/10.1007/s00394-022-02943-7.
Nonnenmacher Y, Hiller K. Biochemistry of proinflammatory macrophage activation. Cell Mol Life Sci (2018). 75(12), 2093-2109. https://doi.org/10.1007/s00018-018-2784-1.
Ozaki H, Sawada S, Osawa T, et al. Muscle size and strength of the lower body in supervised and in combined supervised and unsupervised low-load resistance training. J Sport Sci Med (2020). 19(14), 721-726. https://www.jssm.org/jssm-19-721.xml>abst.
Paulsen G, Crameri R, Benestad HB, et al. Time course of leukocyte accumulation in human muscle after eccentric exercise. Med Sci Sports Exerc (2010). 42(1), 75-85. https://doi.org/ 10.1249/MSS.0b013e3181ac7adb.
Peng Y, Ao M, Dong B, et al. Anti-inflammatory effects of curcumin in the inflammatory diseases: Status, limitations and countermeasures. Drug Des Devel Ther (2021). 15(1), 4503-4525. https://doi.org/10.2147/DDDT.S327378.
Rahardjo B, Widjajanto E, Sujuti H, Keman K. Curcumin decreased level of proinflammatory cytokines in monocyte cultures exposed to preeclamptic plasma by affecting the transcription factors NF-κB and PPAR-γ. Biomarkers Genomic Med. (2014). 6(3), 105-115. https://doi.org/10.1016/j.bgm.2014.06.002.
Sharma M, Sahu K, Singh SP, Jain B. Wound healing activity of curcumin conjugated to hyaluronic acid: in vitro and in vivo evaluation. Artif Cells, Nanomedicine, Biotechnol (2018). 46(5), 1009-1017. https://doi.org/10.1080/21691401.2017.1358731.
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