Modulação de biomarcadores de stress oxidativo induzido pelo exercício pela suplementação nutracêutica com moringa oleifera em jogadores de futebol: um ensaio clínico randomizado duplo-cego
DOI:
https://doi.org/10.47197/retos.v74.117332Palavras-chave:
Resposta antioxidante, recuperação pós-exercício, estratégia nutricional, dano oxidativo, treino de resistênciaResumo
Introdução: A homeostasia redox é perturbada pelo aumento da intensidade do exercício, levando a níveis elevados de espécies reativas de oxigénio (EROs). Este desequilíbrio oxidativo é caracterizado pela redução da atividade de enzimas antioxidantes, como a superóxido dismutase (SOD), e pelo aumento de marcadores de peroxidação lipídica, como o malondialdeído (MDA). A Moringa oleifera (MO), rica em polifenóis e flavonoides, é considerada benéfica para a redução do stress oxidativo.
Objectivo: Este estudo teve como objectivo avaliar os efeitos agudos da suplementação com MO nos biomarcadores de stress oxidativo após exercício de carga máxima em jogadores de futebol treinados.
Método: Foi realizado um ensaio clínico randomizado, duplo-cego e controlado por placebo com 22 jogadores de futebol do sexo masculino treinados. Os participantes receberam 1000 mg de MO ou placebo antes de realizarem agachamentos de alta intensidade até à exaustão. Os dados foram analisados utilizando testes t emparelhados e correlação de Pearson (p < 0,05).
Resultados: Os dados iniciais não mostraram diferenças significativas, mas o grupo MO apresentou níveis significativamente mais elevados de SOD e níveis mais baixos de MDA em comparação com o grupo placebo 1 e 24 horas após o exercício (p < 0,01), com fortes correlações negativas entre SOD e MDA às 1 hora (r = –0,50, p = 0,02) e 24 horas (r = –0,71, p < 0,001).
Discussão: A suplementação aguda com MO aumenta a defesa antioxidante endógena e reduz o dano oxidativo após esforço físico máximo.
Conclusão: Estes achados apoiam o uso da MO como suplemento de recuperação de origem local no desporto, particularmente útil para mitigar o stress oxidativo em atletas de alto rendimento.
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Direitos de Autor (c) 2025 Yetty Septiani Mustar, Bayu Agung Pramono, Muhammad Muhammad, Chia-Hua Kuo, Nining Widyah Kusnanik, Agus Hariyanto
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